Application value of liver/spleen CT value,controlled attenuation parameter,and magnetic resonance imaging-proton density fat fraction in chronic hepatitis B patients with hepatic steatosis
Objective To investigate the application value of liver/spleen CT value(CTL/S),controlled attenuation parameter(CAP),and magnetic resonance imaging-proton density fat fraction(MRI-PDFF)in chronic hepatitis B(CHB)patients with hepatic steatosis.Methods A retrospective analysis was performed for the clinical data of 213 CHB patients who underwent liver CT,CAP,and MRI-PDFF examinations in Affiliated Hospital of Yan'an University from October 2018 to December 2022.According to MRI-PDFF,the 213 patients were divided into CHB group with 111 patients(MRI-PDFF<5%)and CHB+hepatic steatosis group with 102 patients(MRI-PDFF≥5%),among whom there were 69 patients with mild hepatic steatosis and 33 patients with moderate to severe hepatic steatosis.The independent-samples t test was used for comparison of normally distributed continuous data between groups,and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups.The Bland-Altman plot was used to evaluate the consistency in MRI-PDFF measurement between two physicians.The Spearman's correlation coefficient was used to analyze the correlation between CTL/S and MRI-PDFF and between CAP and MRI-PDFF.The receiver operating characteristic(ROC)curve was plotted and the area under the ROC curve(AUC)was calculated to investigate the value of CTL/S and CAP in the diagnosis of different degrees of hepatic steatosis,and the DeLong test was used to compare the AUCs of the two radiological examinations.Results MRI-PDFF had relatively high repeatability and stability in CHB patients.There is a significant negative correlation between CTL/S and MRI-PDFF(r=-0.800,P<0.001)and a significant positive correlation between CAP and MRI-PDFF(r=0.692,P<0.001).Both CTL/S and CAP had a relatively high accuracy in the diagnosis of hepatic steatosis in CHB patients,with an AUC of 0.951 and 0.902,respectively,and CTL/S had a better accuracy than CAP(P<0.05).In the diagnosis of mild and moderate-to-severe hepatic steatosis,CTL/S had an AUC of 0.921 and 0.895,respectively,and CAP had an AUC of 0.859 and 0.825,respectively,suggesting that CTL/S had a slightly higher diagnostic efficiency than CAP.Conclusion MRI-PDFF has high repeatability and stability in CHB patients,and CTL/S and CAP have a high diagnostic value for different degrees of hepatic steatosis in CHB patients.
国家科技期刊平台
NSTL
万方数据
维普
