The role and impact of macrophages in the pathogenesis of primary biliary cholangitis
Primary biliary cholangitis(PBC)is a chronic autoimmune disease of cholestasis in which immune factors lead to progressive small bile duct destruction,cholestasis,and eventually liver fibrosis,liver cirrhosis,and even liver failure.Macrophages,as a group with functional heterogeneity,play different roles in the whole disease process of PBC.This article summarizes the possible ways by which macrophages are involved in the pathogenesis of PBC and discusses their impact on the disease and the potential therapeutic targets of macrophages.It is pointed out that macrophages are mainly involved in innate immunity in PBC injury and are associated with gut microbiota dysbiosis,and they are also associated with cholestasis,liver fibrosis,and liver cirrhosis in the later stages of the disease.
国家科技期刊平台
NSTL
万方数据
维普
