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外泌体在肝内胆管癌中的作用

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肝内胆管癌(ICC)是一种特殊类型的肝癌,其早期临床症状不典型,大多数患者初诊时已处于中晚期.由于缺乏有效的分子标志物和治疗手段,ICC患者5年生存率极低.外泌体是一种细胞分泌的囊泡,包含蛋白质、RNA、脂质等,是细胞间通讯的重要载体.近期研究显示外泌体在ICC发生发展过程中扮演重要角色,本文就外泌体在ICC中的诊断、治疗作用及其机制进行综述,并展望外泌体的治疗前景与潜在的临床应用.
Role of exosomes in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma(ICC)is a special type of liver cancer with atypical clinical symptoms in the early stage,and most patients are already in the advanced stage at the time of initial diagnosis.Due to a lack of effective molecular markers and treatment options,ICC patients tend to have an extremely low five-year survival rate.Exosomes are vesicles secreted by cells that contain proteins,RNA,and lipids,and they are important carriers of intercellular communication.Recent studies have shown that exosomes play a crucial role in the development and progression of ICC,and this article reviews the role and mechanism of exosomes in the diagnosis and treatment of ICC and looks into the future treatment prospect and potential clinical application of exosomes.

CholangiocarcinomaExosomesDiagnosisTherapeutics

唐晋元、杨陈凤麟、梁冬乐、罗雨豪

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西南医科大学附属医院肿瘤科,四川 泸州 646000

廊坊市人民医院肿瘤科,河北 廊坊 065000

胆管上皮癌 外泌体 诊断 治疗学

国家自然科学基金四川省自然科学基金

8190300081903000

2024

临床肝胆病杂志
吉林大学

临床肝胆病杂志

CSTPCD北大核心
影响因子:1.428
ISSN:1001-5256
年,卷(期):2024.40(1)
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