首页|半乳糖凝集素-9(Gal-9)介导的免疫调节作用在肝脏疾病中的研究进展

半乳糖凝集素-9(Gal-9)介导的免疫调节作用在肝脏疾病中的研究进展

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半乳糖凝集素-9(Gal-9)是能够特异性识别、结合半乳糖苷的半乳糖凝集素家族成员之一.近年研究发现,Gal-9在肝脏中高水平表达,有助于维持肝内免疫稳态并在多种肝脏疾病中发挥生物学功能.本文综述了Gal-9的免疫调节功能及其在不同肝脏疾病中的作用.Gal-9在不同肝脏疾病中通过多种途径发挥重要的生物学功能,基于对Gal-9具体免疫调节机制和功能的研究,有助于发现Gal-9在肝脏疾病中的治疗作用.
Research advances in the immunomodulatory mechanism of galectin-9 and its role in liver diseases
Galectin-9(Gal-9)is a member of the galectin family that can specifically recognize and bind to galactosides.Recent studies have shown that Gal-9 is highly expressed in the liver and can help to maintain intrahepatic immune homeostasis and perform biological functions in various liver diseases.This article reviews the immunomodulatory functions of Gal-9 and its role in different liver diseases.Studies have shown that Gal-9 has important biological functions in different liver diseases through multiple pathways.Research on the specific immunomodulatory mechanisms and functions of Gal-9 may help to discover the therapeutic role of Gal-9 in liver diseases.

Galectin-9ImmunomodulationLiver Diseases

凌珺、朱冰、陈威巍、王卓然、余丽梅、游绍莉

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遵义医科大学附属医院贵州省细胞工程重点实验室,贵州 遵义 563003

中国人民解放军总医院第五医学中心肝病医学部,北京 100039

半乳糖凝集素-9 免疫调节 肝脏疾病

国家科技重大专项国家重点研发计划

2017ZX102032012017ZX10203201

2024

临床肝胆病杂志
吉林大学

临床肝胆病杂志

CSTPCD北大核心
影响因子:1.428
ISSN:1001-5256
年,卷(期):2024.40(1)
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