肝硬化凝血障碍机制的再认识
Re-understanding of the mechanism of coagulation disorder in liver cirrhosis
孙荣荣 1贺娜 2张粉娜 2张心怡 3王梓依 3王辉 3边娜娜 3闫红林2
作者信息
- 1. 西安医学院第一附属医院消化内科,西安 710077;西安医学院研究生院,西安 710021
- 2. 西安医学院第一附属医院消化内科,西安 710077
- 3. 西安医学院研究生院,西安 710021
- 折叠
摘要
肝脏在维持机体凝血和抗凝动态平衡中发挥重要调节作用.肝硬化患者抗凝与凝血的动态平衡很脆弱,会因凝血因子减少,血小板计数下降,纤溶亢进而增加出血风险,同时还会因血管性血友病因子、凝血因子Ⅷ升高,抗凝蛋白C、抗凝蛋白S降低,凝血酶生成潜力增加,抗纤溶成分的改变而形成血栓.本文对肝硬化凝血障碍的机制进行综述,以期对临床医生关于肝硬化患者的出血或血栓性疾病的预防和治疗提供帮助.
Abstract
The liver plays an important regulatory role in maintaining the dynamic balance of coagulation and anticoagulation in the body.Such dynamic balance is fragile in patients with liver cirrhosis,and the risk of bleeding can be increased due to reductions in coagulation factors and platelet count and excessive fibrinolysis;meanwhile,thrombus can be formed due to the increases in von Willebrand factor and coagulation factor Ⅷ,the reductions in anticoagulant protein C and anticoagulant protein S,the increase in thrombin-generating potential,and alterations in antifibrinolytic components.This article reviews the mechanisms of coagulation disorder in liver cirrhosis,so as to help clinicians with the prevention and treatment of bleeding or thrombotic disorders in patients with liver cirrhosis.
关键词
肝硬化/血液凝固/出血/血栓形成Key words
Liver Cirrhosis/Blood Coagulation/Haemorrhage/Thrombosis引用本文复制引用
基金项目
陕西省教育科学"十三五"规划课题(SGH20Y1330)
佑安肝病传染病专科医疗联盟专项基金(LM202003)
陕西基础科学(化学、生物学)研究院2022年度基础科学研究计划项目(22JHQ091)
出版年
2024
国家科技期刊平台
NSTL
万方数据