摘要
药物性肝损伤(DILI)的发生率呈逐年上升趋势且损伤机制并不明确,针对DILI的治疗药物、肝脏支持系统及肝移植均有一定的局限性.因此,寻找更安全有效的治疗方法已成为当下研究的热点.间充质干细胞及其外泌体可通过减轻肝脏炎症反应,促进肝细胞增殖及再生、抗肝细胞凋亡,改善氧化应激和免疫调节等机制减轻肝损伤.本文就间充质干细胞及其外泌体在药物性肝损伤治疗中的作用进行简要综述,以期为进一步研究提供参考.
Abstract
The incidence rate of drug-induced liver injury(DILI)is increasing year by year with unknown mechanisms,and the treatment methods for DILI mainly include drugs,liver support systems,and liver transplantation,all of which have certain limitations.Therefore,the search for safer and more effective treatment methods has become a research hotspot at present.Studies have shown that mesenchymal stem cells and their exosomes can alleviate liver injury by reducing liver inflammation,promoting hepatocyte proliferation and regeneration,inhibiting the apoptosis of hepatocytes,improving oxidative stress,and regulating immunity.This article briefly reviews the role of mesenchymal stem cells and their exosomes in the treatment of DILI,so as to provide a reference for further research.
基金项目
甘肃省卫生健康行业科研项目(GSWSKY2023-34)
第九四〇医院研究生导师专项课题(2023YXKY020)
第九四〇医院青年培育项目(2021yxky054)
中央高校优秀青年团队培育项目(31920220065)
甘肃省非感染性肝病临床医学研究中心(21JR7RA017)
国家科技期刊平台
NSTL
万方数据