中性粒细胞胞外诱捕网(NET)与肝脏疾病的关系
Research advances in neutrophil extracellular traps and liver diseases
仁增卓嘎 1杨康洁 2芦永良 2王志鑫 3王海久3
作者信息
- 1. 青海大学附属医院肝胆外科,西宁 810001;拉萨市人民医院麻醉科,拉萨 850000
- 2. 青海大学附属医院检验科,西宁 810001
- 3. 青海大学附属医院肝胆外科,西宁 810001
- 折叠
摘要
中性粒细胞通过释放中性粒细胞弹性蛋白酶和髓过氧化物酶等蛋白酶,形成中性粒细胞胞外诱捕网(NET),在体内发挥免疫防御作用,并参与多种肝病的炎性反应,但其过度释放会加重肝组织损伤,成为肝脏疾病的危险因素之一.近年来,有研究发现NET的过度释放可促进病毒性肝炎、非酒精性脂肪性肝炎、肝脏缺血再灌注损伤等疾病向肝癌进展,阐明NET作用机制对肝脏疾病的诊断和进展过程具有重要意义.本文主要阐述NET在肝脏疾病中的最新研究进展,为肝脏疾病的诊疗和预防提供新的思路.
Abstract
Neutrophils play an immune defense role by releasing the proteases such as neutrophil elastase and myeloperoxidase to form neutrophil extracellular trap(NET)and participate in the inflammatory response of various liver diseases,but the excessive release of NET may worsen liver tissue damage and has thus become one of the risk factors for liver diseases.In recent years,studies have shown that the excessive release of NET can promote the progression of liver diseases(such as viral hepatitis,nonalcoholic steatohepatitis,and hepatic ischemia-reperfusion injury)to liver cancer,and clarifying the mechanism of action of NET is of great importance for the diagnosis and progression of liver diseases.Therefore,this article elaborates on the latest research advances in NET in liver diseases,so as to provide new insights into the diagnosis and treatment of liver diseases and the prevention of liver cancer.
关键词
胞外诱捕网/肝疾病/肝肿瘤Key words
Extracellular Traps/Liver Diseases/Liver Neoplasms引用本文复制引用
基金项目
青海省科技厅临床医学研究中心项目(2017-SF-L2)
出版年
2024
国家科技期刊平台
NSTL
万方数据