氨基酸代谢在非酒精性脂肪性肝病中的作用机制
Mechanism of amino acid metabolism in nonalcoholic fatty liver disease
张慧 1谭明 1程胜桃 1陈娟1
作者信息
- 1. 重庆医科大学感染性疾病分子生物学教育部重点实验室,重庆 010000
- 折叠
摘要
非酒精性脂肪性肝病(NAFLD)是全球最普遍的慢性肝病之一,影响全球约1/4的人口,预计到2030年将成为肝移植的主要适应证.NAFLD可导致包括支链氨基酸在内的多种氨基酸水平显著异常,进而促进NAFLD的发生发展.提示除葡萄糖代谢和脂质代谢外,氨基酸代谢也在NAFLD疾病进展中发挥了重要作用.为系统了解氨基酸代谢在NAFLD中的作用及其机制,本文针对氨基酸代谢在NAFLD中的研究进展进行了综述.拟探讨氨基酸代谢在NAFLD疾病进展中发挥的作用及其相关机制,为临床防治提供思路和理论依据.
Abstract
Nonalcoholic fatty liver disease(NAFLD)is one of the most prevalent chronic liver diseases in the world,affecting about one quarter of the global population,and it is estimated that NAFLD will become the main indication for liver transplantation by 2030.NAFLD can lead to significant abnormalities in the levels of a variety of amino acids including branched-chain amino acids,thereby promoting the development and progression of NAFLD.These results suggest that in addition to glucose and lipid metabolism,amino acid metabolism also plays an important role in the progression of NAFLD.In order to systematically understand the role and mechanism of amino acid metabolism in NAFLD,this article reviews the research advances in amino acid metabolism in NAFLD.This article aims to explore the role and mechanism of amino acid metabolism in the progression of NAFLD,so as to provide ideas and a theoretical basis for clinical prevention and treatment.
关键词
非酒精性脂肪性肝病/氨基酸类/代谢组学Key words
Non-alcoholic Fatty Liver Disease/Amino acids/Metabolomics引用本文复制引用
基金项目
国家自然科学基金面上项目(82273423)
国家自然科学基金青年基金(82202501)
出版年
2024
国家科技期刊平台
NSTL
万方数据