Role of the Hedgehog signaling pathway in hepatocellular carcinoma and its tumor microenvironment
The Hedgehog(Hh)signaling pathway plays an important role in the development and progression of hepatocellular carcinoma and its tumor microenvironment,and abnormal activation of Hh signal can accelerate the growth of tumor.The crosstalk between the Hh signaling pathway and TME is closely associated with tumor growth and the formation of inhibitory tumor microenvironment.Evidence shows that inhibition of Hh signal plays an important role in inhibiting the growth of hepatocellular carcinoma.This article reviews the current research status of the role,mechanism,and potential therapeutic significance of abnormal activation of Hh signal in hepatocellular carcinoma and its tumor microenvironment,so as to provide new ideas for the treatment of hepatocellular carcinoma.
国家科技期刊平台
NSTL
万方数据
