肝衰竭并发急性胰腺炎的机制及预防
Mechanism and prevention of liver failure complicated by acute pancreatitis
陆星宇 1杨晶 1李盼 1彭建平1
作者信息
- 1. 湖南中医药大学第一附属医院肝病科,长沙 410000
- 折叠
摘要
肝衰竭病情进展快,并发症多,病情十分凶险.在肝衰竭发展过程中,并发急性胰腺炎十分常见;而急性胰腺炎的临床症状及体征与肝衰竭并发自发性腹膜炎极其相似,易被忽略.本文通过炎症反应、十二指肠乳头功能障碍、肠道菌群失调、氧化应激、微循环障碍等5个方面对肝衰竭并发急性胰腺炎的机制进行阐述,并根据其作用机制提出相应预防手段.
Abstract
Liver failure often has rapid progression,multiple complications,and dangerous conditions.Acute pancreatitis is a common comorbidity during the progression of liver failure,and since acute pancreatitis has extremely similar clinical symptoms and signs to liver failure complicated by spontaneous peritonitis,it is often neglected in clinical practice.This article elaborates on the mechanisms of liver failure complicated by acute pancreatitis from the five aspects of inflammatory response,duodenal papillary dysfunction,gut microbiota dysbiosis,oxidative stress,and microcirculatory disturbance and proposes corresponding preventive measures based on these mechanisms.
关键词
肝功能衰竭/胰腺炎,急性坏死性/病理过程/早期医疗干预Key words
Liver Failure/Pancreatitis,Acute Necrotizing/Pathologic Processes/Early Medical Intervention引用本文复制引用
基金项目
湖南省自然科学基金(2022JJ30458)
长沙市科技计划(kq2202451)
出版年
2024
国家科技期刊平台
NSTL
万方数据