乙型肝炎疫苗——从预防到治疗
Hepatitis B vaccine:From prevention to treatment
刘义思 1任姗 1郑素军 1陈新月1
作者信息
- 1. 首都医科大学附属北京佑安医院肝病中心一科,北京 100069
- 折叠
摘要
乙型肝炎疫苗的接种是预防HBV感染最经济、有效的方法.分子生物学和基因工程的进步使得疫苗的制造工艺不断完善,乙型肝炎疫苗也从最开始的血源性疫苗逐渐发展至当下所应用的重组疫苗.预防性乙型肝炎疫苗在临床中已试用于HBsAg清除人群以提高抗-HBs水平,且具有安全性及有效性.并且作为治疗CHB新药的多种靶点之一,基于HBsAg的治疗性乙型肝炎疫苗已经在研发和临床试验中.
Abstract
Hepatitis B vaccination is the most economical and effective way to prevent HBV infection.The advances in molecular biology and genetic engineering have continuously improved the manufacturing process of vaccines,and hepatitis B vaccine has gradually developed from the initial plasma-derived vaccine to the currently used recombinant vaccine.Preventive hepatitis B vaccine has been clinically tested in patients with HBsAg seroclearance to increase the level of anti-HBs,with certain safety and efficacy.As one of the multiple targets for new drugs in the treatment of chronic hepatitis B,a therapeutic hepatitis B vaccine based on HBsAg is already in the stages of research and development and clinical trial.
关键词
乙型肝炎,慢性/乙型肝炎疫苗/临床试验Key words
Hepatitis B,Chronic/Hepatitis B Vaccines/Clinical Trial引用本文复制引用
基金项目
国家重点研发计划(2023YFC2308100)
首都临床诊疗技术研究及转化应用项目(Z211100002921059)
北京市医院管理中心"青苗"人才计划(QML20211702)
北京市卫生健康委高层次公共卫生技术人才建设项目(学科带头人-02-14)
出版年
2024
国家科技期刊平台
NSTL
万方数据