β-葡萄糖醛酸酶(GUS)在原发性肝内胆管结石形成中的作用
Role of β-glucuronidase in the formation of primary intrahepatic stones
李果 1叶海军 1徐至开 1李文涛 1徐承雷 1李江1
作者信息
- 1. 昆明医科大学第一附属医院肝胆外科,昆明 650032
- 折叠
摘要
原发性肝内胆管结石(PIS)是我国西南地区高发和难治性疾病,对患者的生活造成极大的影响.胆道系统慢性感染产生的β-葡萄糖醛酸酶等代谢产物,在色素性结石的形成中起着重要作用,除细菌产生的外源性β-葡萄糖醛酸酶,肝内胆管细胞产生的内源性β-葡萄糖醛酸酶在结石的形成中亦扮演重要角色.本文就PIS发病机制中β-葡萄糖醛酸酶的作用研究进展予以分析,以期为PIS的防治提供可能的方式.
Abstract
Primary intrahepatic stones(PIS)is a refractory disease with a high incidence rate in Southwest China,which greatly affects the life of patients.Metabolites,such as β-glucuronidase produced by chronic biliary tract infection,play an important role in the formation of pigmented stones.In addition to exogenous β-glucuronidase produced by bacteria,endogenous β-glucuronidase produced by intrahepatic bile duct cells also plays an important role in the formation of stones.This article analyzes the research advances in the role of β-glucuronidase in the pathogenesis of PIS,in order to provide a possible method for the prevention and treatment of PIS.
关键词
胆石/葡萄糖醛酸酶/病理过程Key words
Gallstones/Glucuronidase/Pathologic Processes引用本文复制引用
基金项目
云南省科技厅-高校联合基金(202101AY070001-129)
出版年
2024
国家科技期刊平台
NSTL
万方数据