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药物诱导的自身免疫样肝炎的研究进展

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药物诱导的自身免疫样肝炎(DI-ALH)是药物性肝损伤的一种特殊临床表型,与自身免疫性肝炎有相似的临床特征和实验室检查,多数时候通过肝组织活检也无法直接区分,因此正确鉴别DI-ALH与自身免疫性肝炎是临床实践中的重难点.本文总结了DI-ALH的发病机制、临床特点、诊治、预后的研究进展,为临床医生提供此类疾病的诊治思路.
Research advances in drug-induced autoimmune-like hepatitis
Drug-induced autoimmune-like hepatitis(DI-ALH)is a special clinical phenotype of drug-induced liver injury and has similar clinical features and laboratory test results to autoimmune hepatitis,and it is often difficult to distinguish them through liver biopsy.Therefore,correct differential diagnosis DI-ALH and autoimmune hepatitis is a crucial and difficult point in clinical practice.This article analyzes the research advances in the pathogenesis,clinical features,diagnosis and treatment,and prognosis of DI-ALH,in order to provide ideas for the diagnosis and treatment of such diseases among clinicians.

Chemical and Drug Induced Liver InjuryHepatitis,AutoimmuneDiagnosisTherapeutics

李勤荣、尧颖、徐智媛

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昆明医科大学第二附属医院消化内科,昆明 650000

昆明医科大学附属延安医院消化内科,昆明 650051

化学性与药物性肝损伤 肝炎,自身免疫性 诊断 治疗学

国家自然科学基金

82160106

2024

临床肝胆病杂志
吉林大学

临床肝胆病杂志

CSTPCD北大核心
影响因子:1.428
ISSN:1001-5256
年,卷(期):2024.40(6)