首页|T淋巴细胞免疫球蛋白黏蛋白分子3在肝脏疾病发生发展中的作用

T淋巴细胞免疫球蛋白黏蛋白分子3在肝脏疾病发生发展中的作用

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T淋巴细胞免疫球蛋白黏蛋白分子3(Tim-3)是Tim家族中的一员,为近年来研究热点.Tim-3作为负性调节因子通过与不同配体结合发挥不同效应.多种免疫细胞可表达Tim-3,如自然杀伤细胞、树突状细胞和单核细胞,Tim-3对这些免疫细胞功能具有调控作用.近年来大量研究显示Tim-3与肝脏疾病发生发展有着密切关系.本文回顾了近几年Tim-3在不同肝脏疾病及不同细胞中作用及机制的研究,旨在为肝脏疾病的临床诊疗提供更丰富的视角及思路.
Role of T-cell immunoglobulin and mucin domain-containing molecule 3 in the development and progression of liver diseases
T-cell immunoglobulin and mucin domain-containing molecule-3(Tim-3)is a member of the Tim family and has been a research hotspot in recent years.As a negative regulatory factor,Tim-3 exerts different effects by binding to different ligands.Tim-3 is expressed in various types of immune cells,such as natural killer cells,dendritic cells,and monocytes,and Tim-3 has a regulatory effect on the functions of these immune cells.In recent years,a large number of studies have shown that Tim-3 is closely associated with the development and progression of liver diseases.This article reviews the studies on the role and mechanism of Tim-3 in different liver diseases and cells in recent years,in order to provide richer perspectives and ideas for the clinical diagnosis and treatment of liver diseases.

Liver DiseasesT-Cell Immunoglobulin and Mucin Domain-containing Molecule-3Diagnosis

袁诗雨、杨焕焕、唐映梅

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昆明医科大学第二附属医院消化内科,昆明 650101

肝疾病 T淋巴细胞免疫球蛋白黏蛋白分子3 诊断

国家自然科学基金云南省医学领军人才项目云南万人计划中国联合肝脏健康促进中心戊型肝炎防治专项云南省科技人才与平台计划昆明医科大学第二附属医院临床研究项目昆明医科大学第二附属医院临床研究项目

82360108L-2019013YNWR-MY-2018-028CLH2023-F-HEV-08院士专家工作站202305AF1500652020ynlc010ynIIT2021017

2024

10.12449/JCH240632

临床肝胆病杂志
吉林大学

临床肝胆病杂志

CSTPCD北大核心
影响因子：1.428
ISSN：1001-5256
年,卷(期)：2024.40(6)