首页|中草药相关肝损伤的研究进展与挑战

中草药相关肝损伤的研究进展与挑战

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
中草药相关肝损伤发生众多,对中药临床安全用药与产业健康发展等有重要影响,近年来中草药肝损伤研究受到广泛重视并取得显著进展,我国与国际学术组织均制订并更新了相关临床诊疗指南.本文比较分析了近期有关中草药相关肝损伤诊疗指南的特点,继而从毒性机制、临床诊断与病情评估、风险因素与临床防治等方面简述主要进展,提出部分尚未满足的需求、需要重视的研究难点与可能的防治措施.
Research advances and challenges in herb-induced liver injury
Herb-induced liver injury(HILI)shows a high incidence rate and has great impacts on the clinical medication safety of traditional Chinese medicine and the healthy development of the industry.In recent years,the research on HILI has attracted wide attention and made remarkable progress,and related clinical diagnosis and treatment guidelines have been formulated and updated by the academic organizations in China and globally.This article compares the recent guidelines on HILI formulated by different organizations and elaborates on the main achievements in terms of mechanism of toxicity,clinical diagnosis and disease assessment,risk factors,and clinical prevention and treatment,and it also proposes the unmet needs,the research difficulties that need to be taken seriously,and possible prevention and treatment strategies.

Drugs,Chinese HerbalChemical and Drug Induced Liver InjuryToxic MechanismDiagnosisRisk FactorsTherapeutics

刘成海

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上海中医药大学附属曙光医院肝病研究所,上海 201203

上海市中医临床重点实验室,上海 201203

肝肾疾病病证教育部重点实验室,上海 201203

中草药 化学性与药物性肝损伤 毒理机制 诊断 危险因素 治疗学

上海市中医药事业发展三年行动计划上海市科学技术委员会科技创新行动计划医学创新研究专项上海市临床重点专科建设项目

ZY2018-2020-CCCX-500120Z21900100shslczdzk01201

2024

10.12449/JCH240801

临床肝胆病杂志
吉林大学

临床肝胆病杂志

CSTPCD北大核心
影响因子：1.428
ISSN：1001-5256
年,卷(期)：2024.40(8)