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中草药相关肝损伤的管理与治疗

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
由于我国中草药产品应用形式多样,使用人群广泛,用药情况复杂,近年来中草药相关肝损伤等不良反应事件频发,为进一步科学认识中草药相关肝损伤,规范其风险管理与防治措施,本文结合近年的临床研究进展与相关经验,对中草药相关肝损伤的风险管理、临床评价、预防及治疗展开论述.在中药研发生产、上市后的临床应用等多环节,建立涉及中药产品质量控制、患者安全教育、临床医师合理用药、定期监测、分级分型治疗等全方位的中草药相关肝损伤的管控体系,对于预防和处理肝损伤等不良反应事件非常重要,为中草药临床安全合理用药提供参考和借鉴.
Management and treatment of herb-induced liver injury
Due to the diverse application forms of Chinese herbal medicine products,the wide range of users,and the complex conditions of medication in China,adverse events including herb-induced liver injury(HILI)occur frequently in recent years.In order to further understand HILI and standardize its risk management and prevention and treatment measures,this article discusses the risk management,clinical evaluation,prevention,and treatment of HILI based on related clinical research advances and experience in recent years.In the multiple links of traditional Chinese medicine including production and clinical application after marketing,the establishment of a comprehensive control system is of great importance for the prevention and treatment of HILI and other adverse events,involving product quality control,patient safety education,rational drug use by clinicians,regular monitoring,and graded and classified treatment,which provides a reference for the rational and safe clinical use of Chinese herbal medicine in the future.

Drugs,Chinese HerbalChemical and Drug Induced Liver InjuryTherapeutics

孙鑫、罗琼、杨涛、刘成海

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上海中医药大学附属曙光医院 肝病研究所,上海 201203

上海市中医临床重点实验室,上海 201203

上海中医药大学附属曙光医院 心血管病研究所,上海 201203

肝肾疾病病证教育部重点实验室,上海 201203

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中草药 化学性与药物性肝损伤 治疗学

国家中医药管理局高水平中医药重点学科建设项目上海市中医药事业发展三年行动计划上海市科学技术委员会科技创新行动计划医学创新研究专项上海市临床重点专科建设项目

zyyzdxk-2023060ZY2018-2020-CCCX-500120Z21900100shslczdzk01201

2024

10.12449/JCH240806

临床肝胆病杂志
吉林大学

临床肝胆病杂志

CSTPCD北大核心
影响因子：1.428
ISSN：1001-5256
年,卷(期)：2024.40(8)