摘要
近年来对肝硬化发生、发展过程中白细胞介素-1β、白细胞介素-6、白细胞介素-10、白细胞介素-17、肿瘤坏死因子-α、干扰素-γ、C反应蛋白等常见的炎症细胞因子的作用及机制有了更深入的了解,对炎症细胞因子与糖代谢紊乱及胰岛功能受损的相关性研究也取得了较大的进展.本文综述了肝硬化患者炎症细胞因子及其在糖代谢紊乱、胰岛功能受损中的作用,为阐明肝源性糖尿病的发生机制及其临床管理提供理论依据.
Abstract
In recent years,there has been a deeper understanding of the role and mechanisms of common inflammatory cytokines in the development and progression of liver cirrhosis,such as interleukin-1β,interleukin-6,interleukin-10,interleukin-17,tumor necrosis factor-α,interferon-γ,and C-reactive protein,and significant achievements have also been made in the research on the association of these inflammatory cytokines with disorder of glucose metabolism and pancreatic islet dysfunction.This article reviews the role of inflammatory cytokines in patients with liver cirrhosis and their impact on disorder of glucose metabolism and pancreatic islet dysfunction,in order to provide a theoretical basis for clarifying the pathogenesis of hepatogenous diabetes and performing the clinical management of the disease.
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