Therapeutic paradigms and potential therapies for nonalcoholic steatohepatitis
In recent years,steady progress has been made in the epidemiology,pathogenesis,and therapeutic targets of nonalcoholic steatohepatitis(NASH),while there has been slow progress in the field of therapeutic drug development.This article reviews the advances in lifestyle intervention,surgical methods,gut microbiota,and drugs in the treatment of NASH,especially the role of insulin sensitizers,antioxidants,cholesterol-lowering drugs,thyroid hormone mimetics,incretins,and cytokines in the treatment of NASH,in order to provide more methods and options for the treatment of NASH in the future.