摘要
急性胰腺炎是临床上最常见的急腹症之一,胆道疾病、酒精、胰管疾病、代谢障碍如高甘油三酯血症和高钙血症、过度进食、十二指肠降段疾病如十二指肠乳头旁憩室等是急性胰腺炎的常见病因.根据病因将急性胰腺炎分为胆源性胰腺炎、高脂血症性胰腺炎等.胆源性胰腺炎的致病因素很多,在全球范围内,胆道结石等胆系疾病仍是胆源性胰腺炎最主要的病因.各种病因导致的胆胰管排流不畅及压力异常、胆汁向胰管反流、胰液引流受阻、胰酶异常活化是导致胆源性胰腺炎发生的中心环节.胆道结石所在部位、结石大小、质地、数目、形状等与胆源性胰腺炎的发病率及严重程度一定的关系.
Abstract
Acute pancreatitis is one of the most common acute abdominal diseases in clinical practice,and the common etiologies of acute pancreatitis include biliary diseases,alcohol,pancreatic duct diseases,metabolic disorders(hypertriglyceridemia and hypercalcemia),excessive eating,and diseases of the descending duodenum(periampullary duodenal diverticula).According to the etiology,acute pancreatitis is classified into biliary pancreatitis and hyperlipidemic pancreatitis,and although there are various pathogenic factors for biliary pancreatitis,biliary diseases including bile duct stones remain the most important etiology of biliary pancreatitis.Obstructed biliopancreatic duct drainage and abnormal pressure due to various causes,bile reflux into the pancreatic duct,obstruction of pancreatic juice drainage,and abnormal activation of pancreatic enzymes are the central links in the development of biliary pancreatitis.The location,size,texture,number and shape of bile duct stones are associated with the incidence rate and severity of biliary pancreatitis to a certain degree.
基金项目
济南市临床医学科技创新计划项目(202328034)
国家科技期刊平台
NSTL
万方数据