双硫死亡在非酒精性脂肪性肝病中的作用机制
Mechanism of action of disulfidptosis in nonalcoholic fatty liver disease
严丽沙 1陈煜 1王学士 1冯宪敏 2孙洁2
作者信息
- 1. 吉林医药学院 临床学院,吉林吉林 132013
- 2. 吉林医药学院 基础医学院,吉林吉林 132013
- 折叠
摘要
双硫死亡是近年来提出的一种新型细胞死亡方式,其本质为烟酰胺腺嘌呤二核苷酸磷酸不足而导致的二硫化物应激性死亡.非酒精性脂肪性肝病(NAFLD)是一类以脂肪浸润为主要病理特征,与胰岛素抵抗和遗传易感性密切相关的代谢性疾病.最新研究显示,双硫死亡产生的二硫化物应激可导致肝细胞死亡,从而加快NAFLD的进展.本文就双硫死亡在NAFLD中的最新研究予以总结和分析,以期探讨双硫死亡在NAFLD中的应用潜力,为NAFLD的防治提供新思路.
Abstract
Disulfidptosis is a novel pattern of cell death caused by disulfide stress and inadequate NADPH.Nonalcoholic fatty liver disease(NAFLD)is a group of metabolic diseases with the main pathological feature of fatty infiltration,and it is closely associated with insulin resistance and genetic susceptibility.Currently,the latest studies have shown that disulfide stress caused by disulfidptosis can result in hepatocyte death,thereby accelerating the progression of NAFLD.This article summarizes and analyzes the latest studies on disulfidptosis in NAFLD,in order to explore the application of disulfidptosis in NAFLD and provide new ideas for the prevention and treatment of NAFLD.
关键词
非酒精性脂肪性肝病/双硫死亡/病理过程Key words
Non-alcoholic Fatty Liver Disease/Disulfidptosis/Pathologic Processes引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据