氨基酸代谢重编程对肝细胞癌免疫微环境的影响
Effect of amino acid metabolic reprogramming on immune microenvironment of hepatocellular carcinoma
刘晓丽 1谭钦文 1徐健 1陈焕灵 1余洁 1卢露 1戴明侃 1黄晶晶 2黄鸿娜 3毛德文4
作者信息
- 1. 广西中医药大学研究生院,南宁 530200
- 2. 广西中医药大学第一附属医院 脾胃肝病科,南宁 530023
- 3. 广西中医药大学第一附属医院 中内教研室,南宁 530023
- 4. 广西中医药大学第一附属医院 肝病科,南宁 530023
- 折叠
摘要
肿瘤免疫微环境是由肿瘤免疫细胞及其分泌的细胞因子构成的肿瘤局部外环境,对肿瘤的发生和发展具有一定调控作用.在肝细胞癌的治疗中,氨基酸代谢及其对增殖细胞代谢的重编程日益受到关注,显示出在调控肿瘤免疫微环境中的潜力.尽管氨基酸代谢重编程被视为治疗肿瘤的新途径,但其在调控肝细胞癌中肿瘤免疫的具体机制尚未明确.本文深入探讨了氨基酸代谢在肝细胞癌肿瘤免疫微环境中的作用机制及其临床应用前景,旨在为肝癌的免疫治疗研究提供新的思路.
Abstract
Tumor immune microenvironment is a local external tumor environment composed of tumor immune cells and the cytokines secreted by these cells,and it plays a regulatory role in the development and progression of tumors.In the treatment of hepatocellular carcinoma,amino acid metabolism and its reprogramming of proliferating cell metabolism have attracted more and more attention,showing potential in regulating the tumor immune microenvironment.Although amino acid metabolic reprogramming is regarded as a novel approach for tumor therapy,its specific mechanism remains unclear in the regulation of tumor immunity in hepatocellular carcinoma.This article discusses the mechanism of action of amino acid metabolism in the tumor immune microenvironment of hepatocellular carcinoma and its application prospect in clinical practice,in order to provide new ideas for immunotherapy for liver cancer.
关键词
癌,肝细胞/肿瘤微环境/氨基酸类/代谢/免疫调节Key words
Carcinoma,Hepatocellular/Tumor Microenvironment/Amino Acids/Metabolism/Immunomodulation引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据