摘要
胰腺癌是消化道常见的恶性肿瘤之一,近年发病率逐步升高.其病理类型主要包括导管腺癌、小腺体癌、腺泡细胞癌等,其中导管腺癌是最常见的病理类型.多学科诊疗(MDT)是胰腺癌的新诊疗模式,通过集合不同的医疗团队,包括肝胆外科、消化内科、内分泌科、影像科和放疗科等,共同讨论患者的病情、制订治疗方案及后续管理,以确定最佳的个体化治疗方案.随着精准治疗的概念不断明确和发展、相关基因突变的发现,使得胰腺癌治疗前景更加广泛,个体化治疗更加深入,为改善患者治疗结果提供了机会.本文归纳了在MDT医疗模式下各学科之间的交互情况,并总结该模式下胰腺癌治疗方案的发展趋势和选择方向,指出了目前正在开展的工作及围绕未来胰腺癌MDT的研究方向.
Abstract
Pancreatic cancer is a common malignant tumor of the digestive tract,and the incidence of pancreatic cancer has been gradually increasing in recent years.The main pathological types of pancreatic cancer include ductal adenocarcinoma,small gland carcinoma,and acinar cell carcinoma,among which duct adenocarcinoma is the most common pathological type.Multidisciplinary diagnosis and treatment(MDT)is a new diagnostic and therapeutic mode for pancreatic cancer,and different medical teams,including hepatobiliary surgery,gastroenterology,endocrinology,radiology,and radiotherapy,are gathered to discuss the conditions of patients and develop treatment regimens and subsequent management measures,so as to determine the optimal individualized treatment regimen.With the continuous clarification and development of the concept of precision therapy and the discovery of related gene mutations,promising prospects and individualized treatment have been achieved for the treatment of pancreatic cancer,thereby providing opportunities for improving the treatment outcome of patients.This article analyzes the interaction between different disciplines under the model of MDT,discusses the development trend and directions of the treatment regimens for pancreatic cancer,summarizes the current research work for pancreatic cancer,and proposes the future research directions for MDT in pancreatic cancer.
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