Objective To investigate the clinical effect of transforaminal lumbar interbody fusion(TLIF)under the application of robot navigation combined with endoscopy in the treatment of lumbar disc herniation.Methods The 98 patients with lumbar disc herniation who underwent surgical treatment were divided into observation group(32 cases,using TLIF under the application of robot navigation combined with endoscopy)and control group(66 cases,using posterior lumbar interbody fusion technique),according to different treatment methods.Operation duration,intraopera-tive blood loss,postoperative drainage volume,length of hospital stay and complications were recorded.Pain VAS was used to evaluate the improvement of pain,and ODI was used to evaluate spinal function.Results All patients were followed up for 12~22 months.The operation duration in observation group was longer than that of control group(P<0.01).The intraoperative blood loss,postoperative drainage volume and length of hospital stay in the observation group were less(shorter)than those in the control group(P<0.01).There was no statistical significance in the inci-dence rate of complications between the two groups(P>0.05).The pain VAS and ODI in both groups were decreased at 1 week,1,3,6,12 months after surgery than the preoperation(P<0.05).Observation group was lower than the control group(P<0.01).Conclusions Robot-guided endoscopy assisted TLIF for treatment of lumbar disc hernia-tion is featured with less trauma,better improvement of pain and faster recovery of spinal function.