Objective To investigate the effect of locking plate internal fixation with small incision along dermato-glyph for treatment of midclavicular fracture.Methods The 60 cases of midclavicular fractures were divided into minimally invasive group(29 cases were treated with locking plate internal fixation with small incision along demato-glyph)and traditional group(31 cases were treated by traditional open reduction locking plate internal fixation),ac-cording to different incisions.The operation situation,fracture healing and supraclavicular nerve injury were recorded.Postoperative scar status was evaluated by the Vancouver scar score.Satisfaction with postoperative scar was investiga-ted by questionnaires.Constant-Murley score and disabilities of the arm,shoulder and hand(DASH)score were used to evaluate shoulder joint and upper limb overall function.Results All patients were followed up for 12~18 months.The total incision length and intraoperative blood loss in the minimally invasive group were shorter(less)than those in the traditional group(P<0.05),and there were no statistical differences in operation time and fracture healing time between the two groups(P>0.05).At 2 weeks after surgery,the incidence of supraclavicular nerve injuries in mini-mally invasive group was lower than that in traditional group(P<0.05).One year after surgery,Constant-Murley score and DASH score showed no statistical differences between the two groups(P>0.05).The Vancouver scar score and scar appearance satisfactory rate of patients in the minimally invasive group were better than those in the tradition-al group(P<0.05).Conclusions The treatment of midclavicular fracture with small incision and locking plate fixa-tion has the advantages of small incision,less bleeding,less postoperative scar and lower supraclavicular nerve inju-ries,and the efficacy is satisfactory.