Objective To investigate the efficacy of reserving pronator quadratus internal fixation via musle-bone channel of inferior pronator quadratus in the treatment of distal radius fracture.Methods The 100 patients with distal radius fractures were divided into control group(54 cases were treated with inverted L-shaped incision opening pronaotor quadratus internal fixation)and observation group(46 cases were treated with reserving pronator quadratus internal fixation via musle-bone channel of inferior pronator quadratus),according to whether or not reserving pronator quadratus.Fracture reduction and healing,pain VAS,wrist imaging indicators,range of motion of the forearm and wrist,Gartland-Werley score were recorded.Results All patients were followed up for 12~20 months.Postoperative radiographs showed good alignment of fractures,flat recovery of joint surface and anatomical reduction.The fractures healed well in 2.7~5.5 months.At 6 weeks after operation,pain VAS,pronation and supination ranges of forearm,Gartland-Werley scores were all better in the observation group than those in the control group(P<0.05).At the last follow-up,the forearm pronation activity range in the observation group was larger than that in the control group(P<0.05).There were no statistical differences in forearm supination range and Gartland-Werley scores between the two groups(P>0.05).At the last follow-up,there were no statistical differences in the range of motion of carpal flexion,dorsal extension,palmar inclination and ulnar deviation of the wrist joint between the two groups(P>0.05).Conclu-sions The treatment of distal radius fracture with reserving pronator quadratus internal fixation via musle-bone chan-nel of inferior pronator quadratus can shorten the recovery time,reserve forearm pronation function to the maximum ex-tent,and it is safe and effective.