Objective To investigate the clinical efficacy of posterior spinal endoscopic lamina fenestration combined with nerve decompression for treatment of cervical spondylotic radiculopathy.Methods The 35 cases of cervical spondylotic radiculopathy were received the posterior spinal endoscopic lamina fenestration combined with nerve de-compression.The intraoperative blood loss,operation time,complication and pain VAS were recorded.Clinical efficacy was assessed by the modified MacNab criteria.Results All patients were followed up for 3~7 months.The intraoper-ative blood loss was 10~25(16.94±5.08)ml,the operation time was 70~138(89.58±11.27)min.There were no intraoperative dural tears.No perioperative complications such as injuries of the nerve root,cervical cord,vertebral ar-tery,or intervertebral space infection occurred.The pain VAS at each time-point after operation were decreased than those before operation(P<0.05).At the last follow-up,the effect was assessed with the improved MacNab criteria,the result was excellent in 27 cases,good in 7 cases,fair 1 case,the excellent-good rate was 97.14%(34/35).Con-clusions Posterior spinal endoscopic lamina fenestration combined with nerve decompressionin for treatment of cervi-cal spondylotic radiculopathy is minimal invasive,safe,and which have relibable efficacy.