Objective To investigate the therapeutic effect of artificial bone loaded with antibiotic calcium sulfate on femoral intramedullary nail infection.Methods The 37 cases of femoral intramedullary nail infection were treated with lesion removal+intramedullary nail removal+artificial bone loaded with antibiotic calcium sulfate filling plus external fixator.The following data were recorded,including the erythrocyte sedimentation rate(ESR),C-reactive pro-tein(CRP),white blood cell count(WBC),fracture healing time,removal time of the external fixator,AKS score of knee joint,and the therapeutic effect was evaluated by Tohner-Wrnch criteria.Results All patients were followed up for 10～15(13.91±0.98)months.After debridement,8 patients with larger bone defects were performed with autog-enous iliac bone grafting at 2 months postoperation,and all cases healed well.ESR,CRP and WBC were improved than preoperation at 14 d after operation,there were all statistical differences(P＜0.01).The healing time was 3～7(4.93±0.98)months,and the removal time was 6～9(7.35±0.93)months.At the last follow-up,AKS scores of knee joint were improved from preoperative 70～85(78.53±4.02)points to 140～153(147.03±4.03)points,with statistical significance(P＜0.05).Tohner-Wrnch criteria was used to evaluate the curative effect:25 cases were ex-cellent,8 cases were good,4 cases were fair,and the excellent-good rate was 89.19％.Conclusions Artificial bone loaded with antibiotic calcium sulfate can effectively control intramedullary infection,which has good biocompatibility and can induce osteogenesis,with satisfactory effect.
artificial bone loaded with antibiotic calcium sulfatefemoral intramedullary nail infection
万方数据
维普
