Objective To investigate the clinical effect of posterolateral approach plate and cannulated screw fixation in the treatment of lateral and posterior malleolus fractures.Methods The 124 patients with lateral and posterior malleolus fractures were treated by plate and cannulated screw fixation with posterolateral approach.Incision healing time,fracture healing time,ankle function score and complications were recorded.Results All patients were followed up for 12~26 months.In 117 cases,the incisions healed in the one-stage;in 4 cases,suture removal time was extend-ed to 3 weeks after operation due to exudation;2 cases underwent debridement due to skin necrosis,and 1 case was performed with debridement plus negative pressure drainage due to incision infection.The symptoms of 2 cases of per-oneal tendinitis were improved significantly after symptomatic treatment,and no long flexor contracture was found.All fractures of 124 cases healed in 3~5 months.At the last follow-up,all 124 cases could walk with full weight-bearing,of which 5 cases had mild claudication.ROM of ankle joint:dorsal extension was 20°~28°,plantar flexion was 34°~45°;the ankle joint function was evaluated by Baird-Jackson scoring system:99 cases were excellent,18 cases were good,7 cases were fair,and the excellent-good rate was 94.4%.Conclusions Plate combined with cannulated screw internal fixation can be used to treat the lateral and posterior malleolus fractures with posterolateral approach,which is simple and easy operation,with less soft tissue injuries,and the internal fixation can be recovered well with soft tissue,and the therapeutic effect is satisfactory.