Objective To compare clinical effects between transpedicular screw fixation and transpedicular screw fix-ation plus percutaneous vertebroplasty for treatment of osteoportic thoracolumbar burst fracture.Methods The 46 patients with osteoportic thoracolumbar burst fracture received surgical treatments were retrospectively analyzed in this research,25 patients underwent transpedicular screw fixation(group A),21 patients were reconstructed with transpe-dicular screw fixation plus percutaneous vertebroplasty(group B).Operating time,intraoperative bleeding,postoper-ative time out of bed,occurrence of complications,pain VAS,vertebral height compression rate and Cobb angle were recorded in both groups.Results Patients were followed for 12~23(15.80±2.64)months.Operating time was shorter in group A than group B(P<0.05).Intraoperative bleeding was not statistically different between groups(P>0.05).Postoperative time out of bed was longer in group A than that in group B(P<0.05).Bone cement leakage occurred in 4 patients of group B.Pain VAS were lower in group B than that in group A at 1 week postopera-tively(P<0.05),and there was no statistical significance between two groups at final follow-up(P>0.05).Com-pared with the preoperative period,vertebral height compression rate and Cobb angle were improved in both groups at 1 week postoperatively and at last follow-up(P<0.05);group B was better than group A at last follow-up(P<0.05).Conclusions Compared with percutaneous pedicle screw internal fixation,transpedicular screw fixation plus percutaneous vertebroplasty for osteoporotic thoracolumbar burst fractures can reduce patient pain,shorten patient bedtime,and preserve injured vertebral height,but there is a risk of cement leakage.