Objective To compare the clinical effects of unilateral biportal endoscopy(UBE)technique and interlami-nar percutaneous endoscopic lumbar discectomy(IL-PELD)in the treatment of lumbar disc herniation.Methods The 83 patients with lumbar disc herniation were divided into UBE technique group(37 cases were treated with UBE technique)and IL-PELD group(46 cases were treated with IL-PELD),according to different surgical approaches.The intraoperative fluoroscopy frequency,intraoperative blood loss,operation time,hospital stay time,dural tear rate,recur-rence rate of lumbar disc herniation,VAS of low back and lower limb pain,and ODI index were compared between the two groups.Clinical efficacy was evaluated with modified MacNab criteria at the last follow-up.Results All patients were followed up for 13~33(21.8±5.9)months.Intraoperative blood loss and operation time in IL-PELD group were less(shorter)than those in UBE technique group(P<0.05).There were no statistical differences in intraopera-tive fluoroscopy frequency and hospital day between the two groups(P>0.05).At 3 months after surgery,the VAS of lower back pain in the UBE technique group was higher than that in the IL-PELD group(P<0.01).There were no statistical differences in the other observation and evaluation indicators between the two groups(P>0.05).Conclu-sions Both UBE technique and IL-PELD can achieve good early clinical efficacy in the treatment of lumbar disc her-niation.IL-PELD is minimally invasive,but with limited exposure,which is suitable for the treatment of simple lumbar disc herniation;UBE technique has a wider range of decompression,more thorough decompression,and a smooth learn-ing curve,making it suitable for the treatment of complex lumbar disc herniation.