Objective To investigate the efficacy of modified anteromedial support plate combined with lateral locking plate fixation in the treatment of distal femoral fractures.Methods The 46 patients with distal femoral fractures were divided into a control group(28 cases were treated with simple lateral lockingplate fixation)and an observation group(18 cases were treated with modified anteromedial support plate combined with lateral locking plate fixation),accord-ing to different internal fixation methods.The intraoperative bleeding volume,surgical time,fracture healing time,and knee flexion range of motion were compared between two groups.Results All patients were followed up for 5~16 months.There was no statistical significance in intraoperative bleeding between the two groups(P>0.05);the surgi-cal time in the control group was shorter than that in the observation group(P<0.01);the fracture healing time and knee joint flexion range of motion at 5 months after surgery were shorter(larger)in the observation group,compared with the control group(P<0.01).Conclusions The combination of modified anteromedial support plate and lateral locking plate fixation for the treatment of distal femoral fractures can fully expose the fracture end,with reliable reduc-tion and fixation effects.It has the advantages of shortening fracture healing time and facilitating early knee joint exer-cise for patients,but there is also shortcoming of prolonging surgical time.