Clinical effect of rosuvastatin calcium tablets combined with metoprolol succinate sustained-release tablets in the treatment of coronary heart disease complicated with arrhythmia
Clinical effect of rosuvastatin calcium tablets combined with metoprolol succinate sustained-release tablets in the treatment of coronary heart disease complicated with arrhythmia
Objective To observe the clinical effect of rosuvastatin calcium tablets combined with metoprolol succinate-sustained release tablets in the treatment of coronary heart disease complicated with arrhythmia.Methods Ninety-six patients with coronary heart disease complicated with arrhythmia admitted to Shandong University Qilu Hospital from January 2021 to January 2023 were selected as the study objects,and were divided into observation group and control group according to random number table method,with 48 cases in each group.The control group was treated with metoprolol succinate sustained-release tablets,and the observation group was treated with rosuvastatin calcium tablets on the basis of the control group.Both groups were treated for 1 month.The clinical efficacy,cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)]and the frequency of arrhythmia before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 85.42%,which was higher than that of the control group(54.17%)(χ2=11.117,P=0.001).After1 month of treatment,LVEDD and LVESD in two groups were lower than before treatment,LVEF was higher than before treatment,and observation group was lower/higher than control group(P<0.01).The frequency of ventricular precontraction,atrial precontraction and borderline precontraction in two groups were less than before treatment,and those in observation group were less than control group(P<0.01).Conclusion Rosuvastatin calcium tablets combined with metoprolol succinate sustained-release tablets have good clinical efficacy in the treatment of coronary heart disease complicated with arrhythmia,effectively improving coronary blood flow,alleviating myocardial ischemia and hypoxia,and reducing the number of arrhythmia attacks.
维普
万方数据