Effect of sacubitril valsartan on cardiac function in patients with COPD combined with heart failure
Objective To observe the effect of sacubitril valsartan on cardiac function in patients with COPD combined with heart failure(HF).Methods Retrospective analysis was used,341 patients with COPD combined with HF who were hospitalized in Jiangyin People's Hospital from January 2019 to December 2020 were selected,and they were divided into the observation group(n=184)and control group(n=157)based on the different treatment plans.The observation group was treated with sacubitril valsartan,and the control group was treated with valsartan.After 3 months of treatment,the cardiac function indexes(LVEF,LVESD,LVEDD),pulmonary arterial pressure,BNP level,6 min walking distance(6MWD)and the minnesota living with heart failure questionnaire(MLHFQ)score were compared between the two groups.Results After 3 months of treatment,there were no significant changes in LVEF,LVESD,LVEDD and pulmonary artery pressure in the control group compared with before treatment(P＞0.05),whereas in the observation group,LVEF was higher and LVESD,LVEDD,pulmonary artery pressure were lower compared with before treatment and control group(P＜0.05 or P＜0.01).BNP level and MLHFQ score of the two groups were lower and 6MWD was longer than before treatment,BNP level and MLHFQ score of the observation group were lower than those of the control group,and 6MWD was longer than that of the control group(P＜0.05 or P＜0.01).Conclusion Sacubitril valsartan can significantly improve cardiac function and quality of life in patients with COPD combined with HF.
Chronic obstructive pulmonary diseaseHeart failureSacubitril valsartanCardiac function
万方数据
维普
