Clinical effect of Juanbi Huoluo decoction combined with thunder-fire moxibustion in the prevention of oxaliplatin induced peripheral neurotoxicity
Objective To observe the clinical effect of Juanbi Huoluo decoction combined with thunder-fire moxibustion in the prevention of oxaliplatin induced peripheral neurotoxicity.Methods Seventy patients with malignant tumors who received oxaliplatin containing regimen in Jiangyin Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected and randomly divided into herbal soaking+thunder-fire roasting group(35 cases)and vitamin B,group(35 cases).Both groups were treated with oxaliplatin two drug chemotherapy,the vitamin B1 group was treated with vitamin B1 after chemotherapy,and the herbal soaking+thunder-fire roasting group was treated with Juanbi Huoluo decoction combined with thunder-fire moxibustion after chemotherapy.Both groups were treated for 4 cycles.The incidence and grading of peripheral neurotoxicity,motor and sensory nerve conduction velocities of median nerve,left common peroneal nerve and right common peroneal nerve,KPS score before and after treatment,and adverse reactions were compared between the two groups.Results The total incidence of peripheral neurotoxicity in the herbal soaking+thunder-fire roasting group(71.43％)was lower than that in the vitamin B1 group(91.43％),and the degree of toxicity grading was lower than that in the vitamin B1 group(P＜0.05 orP＜0.01).After 4 cycles of treatment,the motor and sensory nerve conduction velocities of median nerve,left common peroneal nerve and right common peroneal nerve in the two groups were greater than those before treatment,and those in the herbal soaking+thunder-fire roasting group were greater than those in the vitamin B1 group(P＜0.05 or P＜0.01).The KPS score of the vitamin B1 group was lower than that before treatment,and the KPS score of the herbal soaking+thunder-fire roasting group was higher than that of the vitamin B,group(P＜0.01).There was no significant difference in the KPS score of the herbal soaking+thunder-fire roasting group compared with that before treatment(P＞0.05).The incidence of blood toxicity,grade and abnormal liver and kidney function in the herbal soaking+thunder-fire roasting group were lower than those in the vitamin B1 group(P＜0.05).Conclusion The application of Juanbi Huoluo decoction combined with thunder-fire moxibustion in cancer patients treated with oxaliplatin chemotherapy can effectively reduce the incidence of peripheral neurotoxicity,protect neurological function,improve the quality of life,and has high safety.
万方数据
维普
