Observation of therapeutic effect of quadruple therapy of Helicobacter pylori based on antibody typing
Objective Based on Helicobacter pylori(Hp)antibody typing,the therapeutic effect of Hp quadruple therapy was observed.Methods A total of 215 patients with Hp infection who were admitted to the Gastroenterology Department of Jiugang Hospital from January 2023 to March 2024 with positive 14C urea breath test were selected as the case group,and were divided into type Ⅰ subgroup(146 cases)and type Ⅱ subgroup(69 cases)according to Hp antibody type.Another 122 healthy subjects were selected as healthy control group.The patients were treated with quadruple therapy for a total course of two weeks.Four weeks after treatment,the negative conversion rate of 14C urea breath test was compared between type Ⅰsubgroup and type Ⅱ subgroup.The levels of gastrointestinal hormones(G-17,PG Ⅰ,PG Ⅱ,PGR),inflammatory factors(IL-6,hs-CRP)before and after treatment,and adverse reactions in subgroups Ⅰ,Ⅱ and healthy control group were compared.Results At four weeks after treatment,the negative conversion rate of 14 C urea breath test in type Ⅰ subgroup was 80.82％(118/146),higher than 72.46％in type Ⅱ subgroup(50/69),but the difference was not statistically significant(x2=1.916,P=0.166).Before treatment,the levels of G-17,PG Ⅰ,PG Ⅱ,IL-6 and hs-CRP in type Ⅰ and type Ⅱsubgroups were higher than those in healthy control group,the PGR levels were lower than those in healthy control group,and the levels of G-17,PG Ⅰ,PG Ⅱ in type Ⅰ subgroup were higher than those in type Ⅱ subgroup,and the PGR levels were lower than those in type Ⅱ subgroup(P＜0.01).Four weeks after treatment,the levels of G-17,PG Ⅰ and PG Ⅱ in type Ⅰsubgroup and type Ⅱ subgroup were decreased,and PGR were increased(P＜0.05 or P＜0.01),but the levels of G-17,PGⅠ,PG Ⅱ in type Ⅰ subgroup and PG Ⅱ in type Ⅱ subgroup were still higher than those in healthy control group,and the PGR in type Ⅰ subgroup was still lower than that in healthy control group(P＜0.05).There was no significant difference in G-17,PG Ⅰ and PGR levels between type Ⅱ subgroup and healthy control group(P＞0.05).Before treatment,the levels of IL-6 and hs-CRP in type Ⅰ subgroup and type Ⅱ subgroup were higher than those in healthy control group,and the levels of IL-6 and hs-CRP in type Ⅰ subgroup were higher than those in type Ⅱ subgroup(P＜0.01).At four weeks after treatment,the levels of IL-6 and hs-CRP in type Ⅰ and type Ⅱ subgroups were lower than before treatment,but higher than those in healthy control group(P＜0.01).There was no significant difference in the incidence of adverse reactions between type Ⅰ subgroup and type Ⅱ subgroup(6.85％vs.5.80％,x2=0.085,P=0.770).Conclusion Different antibody types of Hp had different damage degrees to gastric mucosa,and the type Ⅰ strain had greater damage to gastric mucosa.The treatment effect of quadruple therapy on type Ⅰ Hp infection and type Ⅱ Hp infection was better,and the negative conversion rate of 14C urea breath test for type Ⅰ infection was slightly higher than that for type Ⅱ Hp infection.
万方数据
维普
