Effect of liraglutide combined with insulin degludec on vascular endothelial function and pancreatic islet function in elderly obese patients with type 2 diabetes mellitus
Objective To observe the effect of liraglutide combined with insulin degludec on vascular endothelial function and pancreatic islet function in elderly obese patients with type 2 diabetes mellitus(T2DM).Methods One hundred and fifty-three cases of elderly obese T2DM patients received by Wuyishan Municipal Hospital from January 2021 to December 2023 were selected,and they were divided into observation group(76 cases)and control group(77 cases)by using the randomized numerical table method.The control group was treated with insulin degludec alone,and the observation group was combined with liraglutide on the basis of the control group.After 12 weeks of treatment,the effect of glycemic control,obesity indexes(BMI,abdominal circumference,hip circumference),vascular endothelial function index(NO,ET-1,VEGF),inflammatory factors(IL-6,IL-10,TNF-α),islet function indicators(FINS,FCP,HOMA-IR)before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate of glycemic control in the observation group was higher than that in the control group(98.68％vs.89.61％,x2=4.167,P=0.041).After 12 weeks of treatment,BMI and the levels of ET-1,VEGF,IL-6,TNF-α,FINS,FCP and HOMA-IR were decreased in the two groups,abdominal circumference and hip circumference were reduced,the levels of NO,IL-10 increased,and the magnitude of change in the observation group was greater than that in the control group(P＜0.01).The difference between the total incidence of adverse reactions in the observation group and the control group was not statistically significant(13.16％vs.15.58％,x2=0.182,P=0.668).Conclusion Liraglutide combined with insulin degludec in the treatment of elderly obese patients with T2DM can significantly improve the effect of glycemic control,reduce the patient's body mass,reduce vascular endothelial damage,regulate the expression of inflammatory factors,improve pancreatic islet function,and no serious adverse reactions occurred,high safety.
Type 2 diabetes mellitus,elderly,obeseLiraglutideInsulin degludecVascular endothelial functionPancreatic islet functionInflammatory factors
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