Clinical effect of vonoprazan fumarate combined with amoxicillin in the treatment of Helicobacter pylori infection
Objective To observe the clinical effect of vonoprazan fumarate combined with amoxicillin in the treat-ment of Helicobacter pylori infection.Methods A total of 62 Helicobacter pylori infected patients admitted to Linyi Central Hospital from January 2023 to January 2024 were selected and divided into study group and control group by random number table method,with 31 cases in each group.The control group was treated with conventional quadruple therapy,and the study group was treated with vonoprazan fumarate combined with amoxicillin.Both groups were treated for 1 month.The clinical effi-cacy,symptom scores and inflammatory indexes(IL-2,TNF-α,IL-6,CRP)levels before and after treatment,eradication rate of Helicobacter pylori,recurrence rate and adverse reactions of two groups were compared.Results The total effective rate of the study group(96.77%)was higher than that of the control group(80.65%)(χ2=4.026,P=0.045).After 1 month of treatment,the scores of epigastric pain and regurgitation,nausea and vomiting in two groups were lower than before treatment,and those in the study group were lower than those in the control group(P<0.05 or P<0.01).The levels of IL-2,TNF-α,IL-6 and CRP in two groups were lower than before treatment,and the levels in study group were lower than those in control group(P<0.01).The eradication rate of Helicobacter pylori the research group was 96.77%,which was higher than that in the control group(80.65%)(χ2=4.026,P=0.045).The recurrence rate of the study group was 3.33%,which was lower than that of the control group(28.00%)(χ2=4.838,P=0.028).The total incidence of adverse reactions in the study group(3.23%)was lower than that in the control group(19.35%)(χ2=4.026,P=0.045).Conclusion The combination of vonoprazan fumarate and amoxicillin in the treatment of Helicobacter pylori infection has good efficacy and high safety,which can improve the symptoms of patients,reduce serum inflammatory indexes,increase the eradication rate of Helicobacter pylori,and reduce the recurrence rate of the disease.
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