Effect of Kangfuxin liquid combined with rabeprazole triple therapy on mucosal healing effect of Hp-related peptic ulcer
Objective To observe the effect of Kangfuxin liquid combined with rabeprazole triple therapy on the mucosal healing effect of peptic ulcer(PU)associated with Helicobacter pylori(Hp).Methods A total of 151 patients with Hp-related PU admitted to Wuyishan Municipal Hospital from February 2020 to August 2023 were selected and divided into Kangfuxin liquid group(n=76)and triple therapy group(n=75)according to random number table method.The triple thera-py group was given triple therapy with rabeprazole,the Kangfuxin liquid group was given Kangfuxin liquid combination therapy with rabeprazole.Both groups were treated continuously for 1 month.The mucosal healing effect,gastrointestinal hormones(GAS,MTL,SS),inflammatory factors(IL-6,IL-17,CRP)before and after treatment,Hp eradication rate and adverse reactions were compared of the two groups.Results The total effective rate of Kangfuxin liquid group was higher than that of triple therapy group(97.37%vs.86.67%,χ2=5.910,P=0.015).After one month of treatment,GAS,MTL,IL-6,IL-17 and CRP levels in the two groups were lower than before treatment,SS level was higher than before treatment,GAS,MTL,IL-6,IL-17 and CRP levels were lower,SS level was higher in the Kangfuxin liquid group(P<0.05 or P<0.01).The Hp clearance rate of Kangfuxin liquid group was higher than that of triple therapy group(92.11%vs.77.33%,χ2=6.380,P=0.012).There was no significant difference in the overall incidence of adverse reactions between Kangfuxin liquid group and triple therapy group(34.21%vs.29.33%,χ2=0.414,P=0.520).Conclusion Kangfuxin liquid combined with rabeprazole triple therapy can increase the Hp clearance rate of Hp-related PU,improve digestive function,reduce inflammatory response,promote mucosal healing,and is safe and effective.
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