Efficacy of tirofiban combined dual antiplatelet therapy in the treatment of acute progressive anterior circulation stroke
Objective To observe the effect of tirofiban combined dual antiplatelet therapy on acute progressive anterior circulation stroke.Methods A total of 149 patients with acute progressive anterior circulation stroke admitted to the Department of Neurology,the First People's Hospital of Kunshan from January 2020 to December 2022 were retrospectively selected,and divided into tirofiban combined DAT group(n=75)and conventional DAT group(n=74)according to different treatment methods.Tirofiban combined DAT group was treated with tirofiban injection followed by aspirin and clopidogrel,and conventional DAT group was treated with aspirin and clopidogrel.A comparison was made of NIHSS scores and Lp-PLA2 levels at baseline,7 days,and 2 weeks after treatment,mRS scores at 3 months after treatment,platelet count at baseline and 2 days after treatment,and coagulation function indicators(PT,TT,APTT)at baseline and 2 weeks after treatment,as well as the occurrence of adverse events within 2 weeks of treatment.Results After 7 days and 2 weeks,NIHSS score and Lp-PLA2 level in two groups were lower than before treatment,and tirofiban combined DAT group was lower than conventional DAT group(P<0.05 or P<0.01).After 3 months of treatment,the proportion of mRS Scores≤2 points in tirofiban com-bined DAT group was higher than that in conventional DAT group(χ2=18.935,P<0.001).After2 days of treatment,PLT in two groups was lower than before treatment,and that in tirofiban combined DAT group was lower than that in conventional DAT group(P<0.01).After 2 weeks of treatment,PT in two groups was longer than before treatment,and the tirofiban combined DAT group was longer than that of conventional DAT group(P<0.01).There were no statistically significant differences in TT and APTT between two groups compared with before treatment or between groups(P>0.05).There was no significant difference in the overall incidence of adverse reactions between the tirofiban combined DAT group and the conventional DAT group(48.00%vs.54.05%,χ2=0.546,P=0.460).Conclusion The combination of tirofiban and dual antiplatelet ther-apy was associated with improved neurological function,favorable outcomes,and decreased Lp-PLA2 levels in patients with acute progressive anterior circulation stroke.
万方数据
维普
