Clinical efficacy of adjuvant treatment of modified Shuxiyiqi Decoction in patients with stable angina pectoris and its impact on cardiac function and quality of life
Clinical efficacy of adjuvant treatment of modified Shuxiyiqi Decoction in patients with stable angina pectoris and its impact on cardiac function and quality of life
Objective To explore the clinical efficacy of adjuvant treatment of modified Shuxiyiqi Decoction in patients with stable angina pectoris and its impact on cardiac function and quality of life.Methods A total of 120 patients with stable angina pectoris receiving treatment in Hainan Hospital of Traditional Chinese Medicine from January 2020 and August 2022 were selected,and divided into observation group and control group by random number table method,each group 60 cases.The control group was treated with conventional western medicine(oral rosuvastatin calcium,isosorbide mononitrate tablets,aspirin enteric-coated tablets,metoprolol tartrate tablets and irbesartan tablets),and the observation group was treated with Shuxiyiqi Decoction plus or less prescription on the basis of the control group.Therapeutic efficacy were compared between the two groups.The exercise tolerance(exercise time,6-minute maximum walking distance,the number of angina attacks,nitroglycerin dos-age),serum indicators[uric acid,hypersensitive C-reactive protein(hs-CRP),fibrinogen(FIB)]levels,and heart function[left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),and stroke output(SV)]levels were compared between two groups before and after treatment.At the same time,changes in patients'living ability were assessed using the Ability of daily living scale(ADL).And the occurrence of adverse reactions between the two groups were compared.Results The overall therapeutic efficacy of the observation group was 88.33％,which was higher than that of the control group(73.33％),and the difference was statistically significant(P＜0.05).After treat-ment,the exercise time of two groups was longer than that before treatment,and the 6-minute maximum walking distance was greater than that before treatment,the number of daily angina attacks and nitroglycerin dosage were lower than those before treatment,the exercise time,6-minute maximum walking distance of the observation group were(6.28±1.05)min,(507.82±10.94)m,respectively,which were higher than those of the control group[(5.89±0.66)min and(437.53±50.62)m],the number of daily angina attacks and nitroglycerin dosage were(0.67± 0.11)times and(0.53±0.09)mg,respectively,which were lower than those of the control group[(1.25±0.24)times and(1.24±0.35)mg],and the differences were statistically significant(P＜0.05).After treatment,the levels of serum uric acid,hs-CRP,and FIB in two groups were lower than those before treatment,and the levels of uric acid and hs CRP in the observation group were(243.74±10.97)μmol/L,(2.35±0.47)mg/L,respectively,which were lower than those in the control group[(302.65±51.10)]µmol/L,(3.04±0.68)mg/L],the differences were statistically significant(P＜0.05),and there was no statistically significant difference in serum FIB levels between the two groups(P＞0.05).There was no statistically significant difference in the total incidence of adverse reactions between the observation group and the control group(16.67％vs.11.67％)(P＞0.05).Conclusion The adjuvant treatment of modified Shuxiyiqi Decoction can effectively im-prove the treatment effect,exercise tolerance,heart function and living ability of stable angina pectoris,improve the patients'homeostasis and exer-cise tolerance,and all have certain safety,which is worthy of clinical promotion.
关键词
稳定性心绞痛/舒胸益气汤/治疗疗效/心功能/生活质量
Key words
Stable angina pectoris/Shuxiyiqi Decoction/Therapeutic effect/Cardiac function/Quality of life
维普
万方数据