Clinical analysis of folic acid receptor-mediated cervical special staining combined with human papillomavirus rapid detection for screening cervical lesions
Clinical analysis of folic acid receptor-mediated cervical special staining combined with human papillomavirus rapid detection for screening cervical lesions
Objective To study the clinical effect of folate receptor-mediated special cervical staining(FRD)combined with human papillomavirus rapid test(Care HPV)in screening cervical lesions.Methods The study method was retrospective analysis.Ninety patients with cervical lesions admitted to Shaw Hospital Affiliated to Nanjing Medical University from January 2018 to December 2022 were divided into the study group(n=45)and the control group(n=45)according to screening methods.The study group underwent FRD combined Care HPV screen-ing.The control group underwent thin-layer liquid-based cytology(TCT)combined with Aptima HPV screening.The detection effect,symp-tom self-assessment effect[self-rating anxiety scale(SAS),self-rating depression scale(SDS),symptom check list 90(SCL-90),the 36-item short form health survey(SF-36)],social and economic effect and complications(abortion syndrome,infection,bleeding)were compared between the two groups.Results There were no statistically significant differences in the detection rate,negative predictive value,positive pre-dictive value,specificity,sensitivity and missed diagnosis rate between the two groups(P＞0.05).There were no statistically significant differ-ences in the scores of SCL-90 and SF-36 between the two groups(P＞0.05).The scores of SAS and SDS in the study group were(53.16± 6.92),(52.26±6.74)points,respectively,which were significantly lower than those in the control group[(56.19±6.75),(55.18±6.63)points],and the differences were statistically significant(P＜0.05).The detection time of the study group was(6.19±1.32)min,which was significantly longer than that of the control group[(2.52±0.89)min],the reporting time was(25.00±3.00)h,which was significantly shorter than that of the control group[(71.00±11.00)h],and the detection cost was(59.00±20.00)yuan,which was significantly lower than that of the control group[(561.00±98.00)yuan],the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of abortion syndrome between the two groups(P＞0.05).The incidence rates of infection and bleeding in the study group were 0 and 8.89％,respectively,which were significantly lower than those in the control group(8.89％and 28.89％),and the differ-ences were statistically significant(P＜0.05).Conclusion Both FRD combined Care HPV screening and TCT combined Aptima HPV screen-ing have significant effects on cervical lesions.However,compared with TCT combined Aptima HPV screening,FRD combined Care HPV screen-ing has shorter reporting time,less testing cost,better patient symptom self-assessment effect and fewer complications.It is more suitable for in-stitutions and regions with relatively backward economic conditions and medical facilities and equipment.
关键词
宫颈病变/叶酸受体介导的宫颈特殊染色/人乳头瘤病毒快速检测/薄层液基细胞学检查/宫颈癌
Key words
Cervical lesions/Folate receptor-mediated specific cervical staining/Rapid detection of human papillomavirus/Thin layer liquid based cytology/Cervical cancer
维普
万方数据