临床和实验医学杂志2024,Vol.23Issue(2) :153-157.DOI:10.3969/j.issn.1671-4695.2024.02.011

快速序贯器官功能衰竭评估评分联合氧合指数与急诊危重症患者危重程度的关系研究

Study on the relationship between the quick sequential organ failure assessment score combined with oxygenation index and the severity of patients with emergency critical

赵向辉 陈乐乐 甄运钰 吴亚光 刘静
临床和实验医学杂志2024,Vol.23Issue(2) :153-157.DOI:10.3969/j.issn.1671-4695.2024.02.011

快速序贯器官功能衰竭评估评分联合氧合指数与急诊危重症患者危重程度的关系研究

Study on the relationship between the quick sequential organ failure assessment score combined with oxygenation index and the severity of patients with emergency critical

赵向辉 1陈乐乐 1甄运钰 1吴亚光 1刘静1
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作者信息

  • 1. 河北省第七人民医院急诊科 河北 保定 073000
  • 折叠

摘要

目的 探讨快速序贯器官功能衰竭评估(qSOFA)评分联合氧合指数(OI)对急诊危重症患者危重程度的预测价值.方法 回顾性选取2020年1月至2021年10月河北省第七人民医院收治的176例急诊危重症患者作为研究对象,包括脓毒症患者92例,社区获得性肺炎患者84例.根据入院24 h内的急性生理学和慢性健康状况评价Ⅱ(A-PACHE Ⅱ)评分结果,将所选患者分为轻度组(15分≤APACHE Ⅱ评分<20分,n=58)、中度组(20分≤APACHE Ⅱ评分<30分,n=70)和重度组(APACHE Ⅱ评分≥30分,n=48).比较3组患者的血气指标[二氧化碳分压(PaCO2)、动脉氧分压(PaO2)、OI]、qSOFA评分;采用Pearson相关分析血气指标与qSOFA评分的相关性;采用多分类有序Logistic回归分析急诊危重症患者危重程度的影响因素;并采用受试者工作特征(ROC)曲线分析qSOFA评分联合OI预测急诊危重症患者危重程度的价值.结果 重度组的PaCO2和qSOFA评分均高于中度组和轻度组,且中度组的PaCO2和qSOFA评分显著高于轻度组,差异均有统计学意义(P<0.05);3组的PaO2和OI呈现下降趋势,重度组低于中度组和轻度组,中度组低于轻度组,差异均有统计学意义(P<0.05).Pearson相关分析结果显示,PaCO2与qSOFA评分呈正相关(r=0.238,P<0.05);PaO2、OI 与 qSOFA 评分呈负相关(r=-0.197、-0.328,P<0.05).多分类有序 Logistic回归分析结果显示,PaCO2和qSOFA评分越高,急诊危重症患者危重程度越严重;但PaO2和OI越低急诊危重症患者危重程度越严重.ROC曲线分析结果示,qSOFA评分联合OI预测急诊危重症患者危重程度的曲线下面积(AUC)最大为0.895,大于各单独指标预测和其他联合指标的预测(P<0.05).结论 qSOFA评分、OI与急诊危重症患者危重程度有关,二者联合预测急诊危重症患者危重程度的价值更高,可作为临床诊断和评估急诊危重症的辅助指标.

Abstract

Objective To investigate the relationship between the quick sequential organ failure assessment(qSOFA)score combined with oxygenation index(OI)and the severity of patients with emergency critical.Methods A total of 176 patients with emergency criticaladmit-ted to the Seventh People's Hospital of Hebei Province from January 2020 to October 2021 were selected as the study subjects,including 92 patients with sepsis and 84 patients with community-acquired pneumonia.According to the results of acute physiology and chronic health status evaluation Ⅱ(APACHE Ⅱ)score within 24 hours after admission,the selected patients were divided into the mild group(15 points≤APACHE Ⅱ score<20 points,n=58),the moderate group(20 points ≤APACHE Ⅱ score<30 points,n=70),and the severe group(APACHE Ⅱ score ≥30 points,n=48).The the blood gas index[partial pressure of carbon dioxide(PaCO2),arterial oxygen(PaO2),OI],and qSOFA score of three groups of patients were collected and compared.The correlation between blood gas index and qSOFA score were analyzed using Pearson correla-tion,the factors affecting the severity of patients with emergency critical were analyzed using ordered multi-classification Logistic regression.The value of the qSOFA score combined with OI in predicting the severity of patients with emergency critical was analyzed by the receiver operating characteristic(ROC)curve.Results PaCO2 and qSOFA score in the severe group were higher than those in the moderate and the mild groups,and PaCO2 and qSOFA score in the moderate group were higher than those in the mild group,the differences were statistically significant(P<0.05).However,PaO2 and OI in the three groups showed a downward trend,the severe group was lower than the moderate group and the mild group,and the moderate group was lower than the mild group,the differences were statistically significant(P<0.05).Pearson correlation analy-sis showed that PaCO2 was positively correlated with qSOFA score(r=0.238,P<0.001).PaO2 and OI were negatively correlated with qSOFA score(r=-0.197,-0.328,P<0.05).Multivariate Logistic regression analysis showed that the higher PaCO2 and qSOFA score,the more severe the emergency critically ill patients were.However,the lower PaO2 and OI,the more serious the emergency critically ill patients were.ROC curve analysis showed that the maximum area under the curve(AUC)of qSOFA score combined with OI in predicting the severity of patients with emergency critical was 0.895,which was greater than that of each individual index and other combined indexes(P<0.05).Conclusion qSO-FA score and OI were related to the severity of patients with emergency critical.The combination of the two was more valuable in predicting the se-verity of patients with emergency critical.It could be used as auxiliary indicators for clinical diagnosis and evaluation severity of patients with emer-gency critical.

关键词

急诊/危重症/危重程度/快速序贯器官功能衰竭评估评分/氧合指数

Key words

Emergency/Critical/Severity/Quick sequential organ failure assessment score/Oxygenation index

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基金项目

河北省卫生健康委科研基金(20211552)

出版年

2024
临床和实验医学杂志
首都医科大学附属北京友谊医院

临床和实验医学杂志

CSTPCD
影响因子:1.504
ISSN:1671-4695
参考文献量15
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