Effect analysis of tetracycline and furazolidone quadruple regimen and conventional regimen in the treatment of Hp-positive chronic a-trophic gastritis in Tibetan area
Effect analysis of tetracycline and furazolidone quadruple regimen and conventional regimen in the treatment of Hp-positive chronic a-trophic gastritis in Tibetan area
Objective To investigate the effect of tetracycline and furazolidone quadruple regimen and conventional regimen in the treat-ment of Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG)in Tibetan area,and attempt to explore the mechanism of action.Methods Eighty Hp-positive CAG patients from Tibetan areas admitted to the Hospital of the Chengdu Office of the People's Government of Ti-bet Autonomous Region from June 2020 to December 2022 were prospectively included.According to the random drawing method,40 cases were divided into the experimental group and the control group.The experimental group was treated with tetracycline and furazolidone quadruple regi-men,while the control group was treated with conventional regimen.The clinical efficacy of the two groups was compared.Before treatment and af-ter treatment,the gastric mucosa with obvious lesions was collected for pathological score,and the serum levels of pepsinogen Ⅰ(PG-Ⅰ),pep-sinogen Ⅱ(PG-Ⅱ),gastrin 17(GA 17),interleukin-6(IL-6)and soluble interleukin-2 receptor(sIL-2R)were compared between the two groups.And the adverse reactions of the two regiments were recorded.Results The efficacy level of the experimental group was better than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the scores of gastric mucosal inflammation,intestinal metaplasia and glandular atrophy in both groups were lower than those before treatment,and the scores of gastric mucosal inflammation and intestinal metaplasia in the experimental group were(1.05±0.16),(1.10±0.47)points,respectively,which were lower than those in the control group[(1.31±0.27),(1.36±0.28)points],the differences were statistically significant(P＜0.05).After treatment,the serum levels of PG-Ⅱ were lower than those before treatment,the levels of PG-Ⅰ and GA17 were higher than those before treatment,and the serum level of GA17 in the experimental group was(1.19±0.28)nmol/L,which was higher than that in the control group[(0.94±0.34)nmol/L],the differences were statistically significant(P＜0.05).After treatment,the levels of serum IL-6 and sIL-2R in two groups were lower than those before treatment,and the levels of serum IL-6 and sIL-2R in the experimental group were(25.62±5.12)ng/mL,(308.74±29.75)KU/L,respectively,which were lower than those in the control group[(30.48±6.90)ng/mL,(341.06±25.74)KU/L],the differences were statistically significant(P＜0.05).The adverse reaction rate of the experimental group was 5.00％,which had no statistically significant differ-ence compared with 12.50％of the control group(P＞0.05).Conclusion Tetracycline and furazolidone quadruple regimen can improve the clinical cure rate of Hp-positive CAG patients in Tibetan area,reduce pathological symptoms,and up-regulate serum GA17 level.The mecha-nism of action may be related to the regulation of IL-6 and sIL-2R.
维普
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