Analysis of the application value of fiberoptic bronchoscopy-protected specimen brush assisted etiological diagnosis in children with se-vere mycoplasma pneumonia
Analysis of the application value of fiberoptic bronchoscopy-protected specimen brush assisted etiological diagnosis in children with se-vere mycoplasma pneumonia
Objective To analyze the application value of fiberoptic bronchoscopy-protected specimen brush(FOB-PSB)assisted eti-ological diagnosis in children with severe mycoplasma pneumonia.Methods A study was conducted on 100 children with severe mycoplasma pneumonia admitted to Yellow River Sanmenxia Hospital from May 2022 to August 2023,using FOB-PSB,electronic bronchoalveolar lavage sam-pling(PBAL),and conventional sputum retention sampling methods.The positive detection rates and pathogen detection rates of the three sam-pling methods were analyzed;And conduct drug sensitivity tests on Gram negative and Gram positive bacteria to analyze the average resistance rate and sensitivity of Gram negative and Gram positive bacteria;Simultaneously evaluate the clinical treatment effect of positive patients adjusted for antibacterial drugs through drug sensitivity testing.Results The positive detection rate of the FOB-PSB sampling method was 93.00％,which was higher than that of the PBAL sampling method and conventional sputum retention method(79.00％,62.00％),and the PBAL sampling method was higher than the conventional sputum retention method,the differenced were statistically significant(P＜0.05).The three sampling methods were mainly Gram-negative bacteria;the detection rate of Gram-negative bacteria by FOB-PSB sampling method was 88.17％,which was significantly higher than that of the PBAL sampling method and conventional sputum retention method(73.42％,64.52％),the difference was statistically significant(P＜0.05).Gram-negative bacteria had high resistance to ampicillin,cefazolin,ceftriaxone and quinolones,and high sensitivity to imipenem,piperacillin,amikacin,aztreonam and tigecycline.Gram-positive bacteria were highly resistant to β-lactams and penicillin,and were highly sensitive to linezolid,rifampicin and vancomycin.The average drug resistance rate and average sensitivity of Gram-negative bacteria and Gram-positive bacteria of the FOB-PSB sampling method were higher than those of the PBAL sampling method and con-ventional sputum retention method,and the PBAL sampling method was higher than the conventional sputum retention method,the differences were statistically significant(P＜0.05).The total effective rate of positive patients after adjustment of antibiotics by drug sensitivity test of the FOB-PSB sampling method was 96.77％,which was higher than that of the PBAL sampling method and conventional sputum retention method(88.61％,75.81％),and the PBAL sampling method was higher than the conventional sputum retention method,the differences were statistically significant(P＜0.05).Conclusion FOB-PSB assisted etiological diagnosis has a high positive detection rate of severe mycoplasma pneumonia in chil-dren,which can effectively identify the infectious pathogens and drug resistance of children,and is conducive to further improving the clinical treatment effect of children.
维普
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