Objective To analyze the correlation of serum tumor suppressor protein M(OSM),thioredoxin 1(Trx-1)and heparin-binding protein(HBP)with the severity of sepsis and the prediction of clinical outcome.Methods A total of 120 patients with Sepsis admitted to Leshan City Shizhong District Peoples Hospital from January 2021 to June 2023 were selected as the research objects.According to the diagnos-tic criteria of sepsis 3.0,they were divided into the sepsis group(n=82)and the septic shock group(n=38).Serum OSM,Trx-1 and HBP levels were detected in all patients,and acute physiology and chronic health status scoring system Ⅱ(APACHE Ⅱ)were performed.Serum OSM,Trx-1 and HBP levels were compared between patients and groups with different APACHE Ⅱ scores.The correlation between serum OSM,Trx-1 and HBP levels and APACHE Ⅱ score was analyzed by Spearman correlation.According to the clinical outcome,the patients were divided into death group and survival group.The serum OSM,Trx-1 and HBP levels of the two groups were compared,and the predictive efficacy of serum OSM,Trx-1 and HBP on the clinical outcome of sepsis was analyzed using receiver operating characteristic(ROC)curve.Results The levels of serum OSM and HBP in the septic shock group were(503.68±123.54)pg/mL,(145.53±36.71)ng/mL,respectively,which were higher than those in the sepsis group[(300.12±56.26)pg/mL,(45.21±10.29)ng/mL],and the level of Trx-1 was(3.23±1.01)ng/mL,which was lower than those in the sepsis group[(6.89±2.57)ng/mL],the differences were statistically significant(P＜0.05).With the in-crease of APACHE Ⅱ score in sepsis patients,serum OSM and HBP levels increased,and Trx-1 levels decreased.There were statistically sig-nificant differences in serum OSM,Trx-1 and HBP levels among APACHE Ⅱ score groups(P＜0.05).By Spearman correlation analysis,APACHE Ⅱ score was positively correlated with serum OSM and HBP levels(P＜0.05),and negatively correlated with Trx-1 level(P＜0.05).The serum OSM and HBP levels in the death group were(600.23±156.86)pg/mL and(168.42±52.31)ng/mL,respectively,which were higher than those in the survival group[(180.16±28.79)pg/mL and(25.09±7.15)ng/mL],and the level of Trx-1 was(1.89 ±0.52)ng/mL,which was lower than those in the survival group[(10.45±3.84)ng/mL],the differences were statistically significant(P＜0.05).According to ROC curve analysis,the area under the curve of serum OSM and Trx-1 combined with HBP in predicting the 28 d death of sepsis patients was 0.921,which was higher than that of single index OSM(0.630),Trx-1(0.686)and HBP(0.606)(P＜0.05).Con-clusion Serum OSM,Trx-1 and HBP are closely related to the severity of sepsis,and the combination of the three can improve the prediction ef-ficiency of clinical outcomes of patients,which is worthy of further study and application.
关键词
硫氧还蛋白质类/急性生理学和长期健康评价/脓毒症/抑癌蛋白M/肝素结合蛋白/严重程度/临床转归
Key words
Thioredoxins/APACHE/Sepsis/Anticancer protein M/Heparin-binding protein/Degree of severity/Clinical outcome
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