Objective To investigate the predictive value of neutrophil-lymphocyte ratio(NLR)and eosinophil count(EOS)on chron-ic obstructive pulmonary disease(COPD)related readmission within 1 year after discharge in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 100 AECOPD patients admitted to the Second Peoples Hospital of Fuyang City from Decem-ber 2020 to June 2022 were included in this retrospective study.Patients with one or more readmission record within one year after discharge were included in the readmission group(n=35),and other patients were included in the non-readmission group(n=65).Clinical data(including general information,laboratory test data,treatment methods,and mortality status)of the two groups were compared.Patients were divided into the high NLR group(n=43)and the low NLR group(n=57),the low EOS group(n=51),and the high EOS group(n=49)according to the cut-off values of receiver operating characteristic(ROC)curves for predicting readmission of AECOPD using NLR and EOS.The hospital stay,COPD related readmission within 1 year and mortality were compared.Logistic regression analysis was conducted to assess the risk of read-mission for AECOPD using NLR and EOS as predictors.Results The hospital stay of patients in the readmission group was(16.68±6.44)days,which was significantly longer than that in the non readmission group[(14.02±6.26)days],the proportion of patients receiving systemic glucocorticoids was 28.57％,which was significantly lower than that in the non readmission group(53.85％),the NLR was 8.57±3.16,which was significantly lower than that in the non readmission group(13.97±3.79),and the EOS was(0.25±0.07)×109/L,which was significantly higher than that in the non readmission group[(0.12±0.06)× 109/L],the differences were statistically significant(P＜0.05).The frequen-cy and proportion of COPD related readmissions within 1 year in the low NLR group were(1.32±0.34)and 46.51％,respectively,which were higher than those in the high NLR group[(0.83±0.31)and 26.32％],the differences were statistically significant(P＜0.05).The number and proportion of COPD related readmission within 1 year in the high EOS group were(1.35±0.40)and 44.90％,respectively,which were higher than those in the low EOS group[(0.81±0.37)and 25.49％],the differences were statistically significant(P＜0.05).Logistic regres-sion analysis showed that low NLR(＜4.85)and high EOS(≥0.1 × 109/L)was associated with the risk of readmission related to COPD within 1 year[OR=4.394(95％CI:1.152-8.203);OR=4.699(95％CI:1.152-8.583)].Conclusion NLR and EOS at admission may be related to COPD related readmission within 1 year after discharge,and can be considered as biomarkers for predicting readmission rates after discharge.
关键词
中性粒细胞与淋巴细胞比值/嗜酸性粒细胞/慢性阻塞性肺病/急性加重期/再入院
Key words
Neutrophil to lymphocyte ratio/Eosinophil/Chronic obstructive pulmonary disease/Acute exacerbation period/Readmission
维普
万方数据