摘要
目的 探讨血清C反应蛋白/白蛋白(CRP/ALB)、免疫球蛋白(Ig)M、IgG对溃疡性结肠炎患者激素干预疗效的预测价值.方法 回顾性选取2020年8月至2022年8月长治医学院附属和平医院收治的行激素干预的溃疡性结肠炎患者80例,经过激素干预后,按照疗效分为有效组60例和无效组20例.收集两组一般资料(年龄、性别、体重指数、病程、病情程度、临床症状)、实验室指标(CRP/ALB、IgM、IgG),观察激素干预后的疗效并对比有效组、无效组的一般资料及临床指标差异,绘制受试者工作特征(ROC)曲线分析CRP/ALB、IgM、IgG预测溃疡性结肠炎患者激素干预疗效的价值,并以多因素Logistic回归分析明确溃疡性结肠炎患者激素干预无效的危险因素.结果 两组年龄、性别、体重指数、病程、病情程度、临床症状比较,差异均无统计学意义(P＞0.05),有效组CRP/ALB、IgM、IgG水平分别为(4.36± 3.12)×10-3、(1.10±0.42)g/L、(1.10±0.42)g/L,均高于无效组[(2.05±5.22)× 10-3、(0.76±0.35)g/L、(9.52± 1.24)g/L],差异均有统计学意义(P＜0.05).经ROC曲线分析证实CRP/ALB、IgM、IgG能够用于溃疡性结肠炎患者激素干预疗效的预测,曲 线下面积分别为 0.839、0.801、0.862,具有较好预测价值(P ＜0.05). 多因素 Logistic 回归分析证实 CRP/ALB＜3.24 ×10-3、IgM ＜0.99 g/L、IgG＜10.15 g/L 为溃疡性结肠炎患者激素干预无效的危险因素(P ＜0.05). 结论CRP/ALB、IgM、IgG能够用于溃疡性结肠炎患者激素干预疗效的预测,且CRP/ALB＜3.24 × 10-3、IgM ＜0.99 g/L、IgG＜10.15 g/L为溃疡性结肠炎患者激素干预无效的危险因素,提示临床在激素干预溃疡性结肠炎时应注意监测上述指标, 对于预测临床疗效具有一定的指导价值.
Abstract
Objective To investigate the predictive value of serum C-reactive protein/albumin(CRP/ALB),immunoglobulin(Ig)M and IgG on the therapeutic effect of hormone intervention in patients with ulcerative colitis.Methods Eighty patients with ulcerative colitis treated with hormone intervention from August 2020 to August 2022 in Peace Hospital Affiliated to Changzhi Medical College were retrospectively selected.After hormone intervention,the patients were divided into the effective group(60 cases)and the ineffective group(20 cases)based on their thera-peutic effects.General data(age,gender,body mass index,course of disease,degree of disease,clinical symptoms)and laboratory indicators(CRP/ALB,IgM,IgG)of the two groups were collected,the efficacy of hormone intervention were observed,and the differences in general data and clinical indicators between the effective group and the ineffective group were compared.The value of CRP/ALB,IgM and IgG in predicting the efficacy of hormone intervention in ulcerative colitis patients was analyzed by receiver operating characteristic(ROC)curve,and the risk factors of ineffective hormone intervention in ulcerative colitis patients were identified by multivariate Logistic regression analysis.Results There were no significant differences in age,gender,body mass index,course of disease,degree of disease and clinical symptoms between the two groups(P＞0.05).The levels of CRP/ALB,IgM and IgG in the effective group were(4.36±3.12)×10-3,(1.10±0.42)g/L and(1.10±0.42)g/L,respectively,which were higher than those in the ineffective group[(2.05±5.22)× 10-3,(0.76±0.35)g/L,(9.52±1.24)g/L],the differences were statistically significant(P＜0.05).ROC analysis proved that CRP/ALB,IgM and IgG could be used to predict the efficacy of hormone intervention in patients with ulcerative colitis,and the areas under the curve were 0.839,0.801 and 0.862,respectively,with good pre-dictive value(P＜0.05).Mnultivariate Logistic regression analysis confirmed that CRP/ALB＜3.24 × 10-3,IgM＜0.99 g/L,IgG＜10.15 g/L were risk factors for ineffective hormonal intervention in patients with ulcerative colitis(P＜0.05).Conclusion CRP/ALB,IgM,IgG can be used to predict the efficacy of hormone intervention in patients with ulcerative colitis,and CRP/ALB＜3.24 × 10-3,IgM＜0.99 g/L,IgG＜10.15 g/L are risk factors for ineffective hormone intervention in patients with ulcerative colitis.It is suggested that the above indexes should be monitored during hormone intervention in ulcerative colitis,which has certain guiding value for predicting clinical efficacy.
维普
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