Analysis of the effect of high-flow nasal cannula oxygen therapy and mask oxygen inhalation therapy on hypoxemia during tracheal in-tubation general anesthesia in patients at high altitude
Analysis of the effect of high-flow nasal cannula oxygen therapy and mask oxygen inhalation therapy on hypoxemia during tracheal in-tubation general anesthesia in patients at high altitude
Objective To explore the effects of high-flow nasal cannula oxygen therapy and mask oxygen therapy on hypoxemia during tracheal intubation general anesthesia in patients at high altitude.Methods A total of 130 surgical patients who underwent general anesthesia for endotracheal intubation in high altitude admitted to Wuwei People's Hospital from May to September 2023 were prospectively selected as the study subjects.They were divided into the observation group and the control group according to random number table method,with 65 patients in each group.Before anesthesia induction,the control group received oxygen inhalation through a mask,while the observation group received high-flow nasal cannula oxygen therapy.The expression levels of mean arterial pressure(MAP),heart rate,general comfort questionnaire(GCQ)score,ar-terial carbon dioxide pressure(PaCO2),arterial oxygen pressure(PaO2)before extubation and after extubation between the two groups of patients were compared,and the incidence of adverse events,non-invasive mechanical ventilation time,reintubation rate,respiratory rate,and lactate clearance rate between the two groups of patients were compared.Results After extubation,the levels of MAP and heart rate in the observation group were(76.82±5.08)mmHg,(83.82±5.08)times/min,which were lower than those in the control group[(87.35±7.12)mmHg,(112.35±7.12)times/min],the differences were statistically significant(P＜0.05).After extubation,the GCQ score of the observation group was(83.65±10.24)points,which was higher than that of the control group[(70.26±6.37)points],the difference was statistically sig-nificant(P＜0.05).After extubation,the levels of PaO2 and PaCO2 in the observation group were(84.65±3.14)and(45.34±4.67)mm-Hg,respectively,which were higher than those in the control group[(71.32±7.16)and(40.62±5.24)mmHg],and the differences were statistically significant(P＜0.05).The incidence of adverse reactions such as facial injury,dry mouth and pharynx,abdominal distension,and skin rupture around the nose in the observation group was 3.08％,which was lower than that in the control group(13.85％),the difference was sta-tistically significant(P＜0.05).There was no statistically significant difference in respiratory frequency between the two groups of patients(P＞0.05);the non-invasive mechanical ventilation time and reintubation rate in the observation group were(9.57±1.46)hours and 3.08％,respec-tively,which were lower than those in the control group[(15.79±2.64)hours and 12.31％],the lactate clearance rate was(14.64±3.57)％,which was higher than that in the control group[(11.25±4.27)％],the differences were statistically significant(P＜0.05).Conclusion The application effect of nasal high-flow nasal cannula oxygen therapy on hypoxemia during tracheal intubation general anesthesia in patients at high altitude is significant.It can further stabilize the patient's vital signs,improve arterial carbon dioxide partial pressure and arterial oxygen par-tial pressure levels,and have a low incidence of adverse reactions.It can lower the rate of re intubation,reduce mechanical ventilation time,and improve lactate clearance rate,which is worthy of clinical application and promotion.
关键词
全身麻醉/气管内插管法/经鼻高流量氧疗/面罩吸氧/高原地区/低氧血症
Key words
General anesthesia/Intratracheal intubation/High-flow nasal cannula oxygen therapy/Mask oxygen inhalation/High alti-tude/Hypoxemia
维普
万方数据