摘要
目的 观察凉血清肺汤辅助窄谱强脉冲光治疗寻常痤疮肺胃热盛证的疗效.方法 前瞻性选取2022年1月至2023年3月北京中医药大学东直门医院收治的82例辩证为肺胃热盛证的寻常痤疮患者为研究对象,按照随机数字表法将其分为脉冲光组和凉血清肺组,每组各41例.脉冲光组给予窄谱强脉冲光治疗,凉血清肺组在窄谱强脉冲光基础上给予凉血清肺汤辅助治疗.检测两组治疗前、治疗3个月后的皮肤生理指标[皮脂分泌率(SER)、皮肤经皮水丢失(TEWL)及pH值]的差异,评估两组治疗前、治疗3个月后的中医症状评分变化,统计两组总有效率和不良反应发生情况.结果 治疗3个月后,两组SER、TEWL及pH值均较治疗前降低,且凉血清肺组治疗3个月后SER、TEWL及pH 值分别为(1.23±0.25)μg/(cm2·min)、(14.02±2.65)g/(h·m2)、4.31±0.42,均低于凉血清肺组[(1.54±0.31)μg/(cm2·min)、(17.25±3.14)g/(h·m2)、5.06±0.47],差异均有统计学意义(P＜0.05).治疗 3 个月后,两组丘疹脓包、面部潮红、瘙痒肿痛、口干黏苦、口臭、大便秘结、小便黄及总分均较治疗前降低,且凉血清肺组治疗3个月后中医症状评分均低于凉血清肺组,差异均有统计学意义(P＜0.05).凉血清肺组总有效率为92.68％,明显高于脉冲光组(75.61％),差异有统计学意义(P＜0.05).脉冲光组发生皮肤刺痛1例,发生皮肤肿胀3例,皮肤干燥2例.凉血清肺组发生胃肠道反应2例,皮肤干燥和皮肤刺痛各1例.两组不良反应发生率比较,差异无统计学意义(P＞0.05).结论 凉血清肺汤辅助窄谱强脉冲光治疗寻常痤疮肺胃热盛证可改善皮肤生理状态指标,减轻症状,提高疗效.
Abstract
Objective To observe the curative effect of Liangxue Qingfei Decoction assisted by narrow-spectrum intense pulsed light in treating acne vulgaris syndrome of lung and stomach heat.Methods A total of 82 patients with acne vulgaris diagnosed with lung and stomach heat excess syndrome admitted to Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine from January 2022 to March 2023 were prospectively selected as the study subjects and divided into the pulsed light group and the Liangxue Qingfei group by random number table meth-od,with 41 cases in each group.The pulsed light group was treated with narrow-spectrum intense pulse light,and the Liangxue Qingfei group was treated with Liangxue Qingfei Decoction on the basis of narrow-spectrum intense pulse light.The differences of skin physiological indexes[se-bum secretion rate(SER),percutaneous water loss(TEWL)sebum secretion rate(SER),percutaneous water loss(TEWL)and pH value]be-tween the two groups were detected before and after 3 months of treatment,the changes of TCM symptom score between the two groups before and after 3 months of treatment were evaluated,and the total effective rate and adverse reactions of the two groups were counted.Results After 3 months of treatment,the SER,TEWL,and pH values of two groups were lower than those before treatment,and the SER,TEWL,and pH values of the Liangxue Qingfei group were(1.23±0.25)μg/(cm2·min),(14.02±2.65)g/(h·m2),4.31±0.42,respectively,which were low-er than those in the pulsed light group[(1.54±0.31)μg/(cm2·min),(17.25±3.14)g/(h·m2),5.06±0.47],the differences were statistically significant(P＜0.05).After 3 months of treatment,papular abscess,facial flushing,pruritus,dry sticky mouth,bad breath,con-stipation,yellow urine and total score of two groups were lower than those before treatment,the TCM symptom scores of Liangxue Qingfei group were lower than those of the pulsed light group after 3 months of treatment,and the differences were statistically significant(P＜0.05).The total effective rate of the Liangxue Qingfei group was 92.68％,which was significantly higher than that of the pulsed light group(75.61％),and the difference was statistically significant(P＜0.05).In the pulsed light group,skin stinging occurred in 1 case,skin swelling occurred in 3 cases and skin dryness occurred in 2 cases.In the Liangxue Qingfei group,gastrointestinal reaction occurred in 2 cases,skin dryness and skin stinging in 1 case respectively.There was no statistically significant difference in adverse reactions between the two groups(P＞0.05).Conclusion Li-angxue Qingfei Decoction assisted narrow-spectrum intense pulse light treatment of acne vulgaris lung and stomach heat excessive syndrome can improve the physiological indicators of skin,reduce symptoms and improve curative effect.
基金项目
北京市自然科学基金(20220901)
横向科研项目(XS5020070258-HR80125146)
维普
万方数据