摘要
目的 观察语言及视空间异常检测在中青年2型糖尿病认知功能障碍预测中的应用价值.方法 研究方法为前瞻性分析,观察对象为2022年1月至2023年6月沧州市人民医院收治入院的80例中青年2型糖尿病患者,将蒙特利尔认知评估量表(MoCA)筛查结果作为分组依据,将糖尿病合并认知功能障碍与单纯糖尿病患者分别纳入观察组(＜26分,n=47)与对照组(≥26分,n=33).记录两组受试者的性别、年龄、体重指数、血压(收缩压、舒张压)水平、文化程度、病程、合并疾病[冠心病、高血压、脑卒中、阻塞性睡眠呼吸暂停低通气综合征(OSAHS)].检测并比较两组患者的MoCA评分、视空间及语言能力评分,分析其与中青年2型糖尿病认知功能障碍的关联性.结果 两组的年龄、体重指数、文化程度、病程、合并OSAHS患者比率比较,差异均有统计学意义(P＜0.05).观察组患者MoCA评分各项目评分及总分均明显低于对照组,差异均有统计学意义(P＜0.05).观察组患者视空间及语言能力评分均明显低于对照组,差异均有统计学意义(P＜0.05).Pearson相关系数分析发现,MoCA评分与视空间、阅读、书写、听理解、复述、语言能力总分均呈正相关(r=0.840、0.849、0.859、0.857、0.867、0.892,P＜0.05).以MoCA量表评分结果为自变量,分别以视空间评分、语言功能总评分作为因变量,进行逐步回归分析,视空间与语言功能评分对MoCA量表总分具有显著的正向预测作用(P＜0.05).结论 中青年2型糖尿病患者认知功能受年龄、文化程度、病程及O SAHS的影响;且语言及视空间异常检测可作为正向预测中青年2型糖尿病认知功能受损的重要工具,具有较高临床价值.
Abstract
Objective Application value of observation language and visual space abnormality detection in predicting cognitive dysfunc-tion of young and middle-aged type 2 diabetes mellitus.Methods This study was a prospective analysis.Eighty young and middle-aged type 2 diabetic patients admitted to Cangzhou People's Hospital from January 2022 to June 2023 were observed.The screening result of Montreal cogni-tive assessment(MoCA)scale was used as the grouping basis,and diabetes with cognitive dysfunction patients and simple diabetes patients were respectively divided into the observation group(＜26 points,n=47)and the control group(≥26 points,n=33).The gender,age,body mass index,blood pressure(systolic and diastolic)levels,educational level,course of disease,and comorbidities[coronary heart disease,hyperten-sion,stroke,obstructive sleep apnea hypopnea syndrome(OSAHS)]of the two groups of participants were recorded.The MoCA scores,visual spatial and language proficiency scores of two groups of patients were tested and compared.And the correlation between them and cognitive dys-function in young and middle-aged people with type 2 diabetes mellitus was analyzed.Results There were significant differences in age,body mass index,education level,course of disease,and the rate of OSAHS between the two groups(P＜0.05).The MoCA scores and total scores of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P＜0.05).The visual space and language ability scores of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P＜0.05).Pearson correlation coefficient found that the MoCA score was positively correlated with the total scores of vis-ual space,reading,writing,listening comprehension,retelling,and language ability(r=0.840,0.849,0.859,0.857,0.867,0.892,P＜0.05).The results of MoCA scale were taken as independent variables,view-space score and total language function score were taken as depend-ent variables,and stepwise regression analysis was performed.View-space score and total language function score had significant positive predic-tive effect on the total score of MoCA scale(P＜0.05).Conclusion The cognitive function of middle-aged and young patients with type 2 dia-betes mellitus is affected by age,educational level,course of disease and OSAHS.Moreover,the detection of language and visual spatial abnor-malities can be used as an important tool for the positive prediction of cognitive impairment in young and middle-aged people with type 2 diabetes mellitus,which has high clinical value.
基金项目
河北省2021年度医学科学研究课题计划项目(20210523)
NETL
NSTL
维普
万方数据